Wiggins Brandon, Deliwala Smit, Banno Fady, Knight Kyle, Minaudo Mark
Internal Medicine, Ascension Health, Grand Blanc, USA.
Internal Medicine, Hurley Medical Center, Flint, USA.
Cureus. 2022 Mar 15;14(3):e23175. doi: 10.7759/cureus.23175. eCollection 2022 Mar.
Collapsing glomerulopathy (CG) is a rare variant of focal segmental glomerulosclerosis (FSGS) that commonly presents as nephrotic syndrome in patients. CG is almost always associated with human immunodeficiency virus (HIV) infection but is rarely from other infectious sources such as parvovirus, Epstein-Barr virus, cytomegalovirus, and SARS-CoV-2. CG has also been reported to be related to other etiologies such as genetic disorders, lupus, malignancy, and post-renal transplant but is exceedingly rare when related to hepatitis C virus (HCV). In this report, we describe the case of a patient presenting with nephrotic syndrome secondary to CG caused by newly diagnosed HCV.
塌陷性肾小球病（CG）是局灶节段性肾小球硬化（FSGS）的一种罕见变体，通常在患者中表现为肾病综合征。CG几乎总是与人类免疫缺陷病毒（HIV）感染相关，但很少源于其他感染源，如细小病毒、爱泼斯坦-巴尔病毒、巨细胞病毒和严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。CG也被报道与其他病因有关，如遗传疾病、狼疮、恶性肿瘤和肾移植后，但与丙型肝炎病毒（HCV）相关时极为罕见。在本报告中，我们描述了一例因新诊断的HCV导致CG继发肾病综合征的患者病例。
