Suppr超能文献

中性粒细胞与淋巴细胞比值作为2型糖尿病患者糖尿病肾病新型标志物的研究

Study of Neutrophil-lymphocyte Ratio as Novel Marker for Diabetic Nephropathy in Type 2 Diabetes.

作者信息

Khandare Sagar Ashokrao, Chittawar Sachin, Nahar Nitin, Dubey T N, Qureshi Zahraan

机构信息

Department of Medicine, Gandhi Medical College and Hamidia Hospital, Bhopal, Madhya Pradesh, India.

Medical Affairs, Zydus Discovery, Ahmedabad, Gujarat, India.

出版信息

Indian J Endocrinol Metab. 2017 May-Jun;21(3):387-392. doi: 10.4103/ijem.IJEM_476_16.

Abstract

INTRODUCTION

Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflammatory marker such as acute myocardial infarction, stroke, and heart failure. In this study, the association of neutrophil-lymphocyte ratio (NLR) with DN is studied.

PATIENTS AND METHODS

It is an observational cross-sectional study. Totally 115 diagnosed type 2 diabetes mellitus patients were registered in this study. NLR was calculated by analyzing differential leukocyte count in complete blood picture. Albuminuria was tested by MICRAL-II TEST strips by dipstick method.

RESULTS

Totally 115 diabetic patients were registered. About 56 patients had DN and 59 had normal urine albumin. Mean NLR for a normal group is 1.94 ± 0.65 and in DN group is 2.83 ± 0.85 which was highly significant ( < 0.001). Estimated glomerular filtration rate ( = 0.047) and serum glutamate pyruvate transaminase ( < 0.001) were also significant.

CONCLUSION

The results of our study show that there was a significant relation between NLR and DN. Therefore, NLR may be considered as a novel surrogate marker of DN in early stages.

摘要

引言

糖尿病肾病(DN)是糖尿病的一种微血管并发症。DN的临床表现为尿白蛋白排泄增加。白细胞总数是一种粗略但敏感的炎症指标,在许多心脏和非心脏疾病中作为炎症标志物进行研究,如急性心肌梗死、中风和心力衰竭。在本研究中,探讨了中性粒细胞与淋巴细胞比值(NLR)与DN的相关性。

患者与方法

这是一项观察性横断面研究。本研究共登记了115例确诊的2型糖尿病患者。通过分析全血细胞计数中的白细胞分类计数来计算NLR。采用尿试纸法用MICRAL-II试纸条检测蛋白尿。

结果

共登记了115例糖尿病患者。约56例患者患有DN,59例尿白蛋白正常。正常组的平均NLR为1.94±0.65,DN组为2.83±0.85,差异具有高度显著性(<0.001)。估计肾小球滤过率(=0.047)和血清谷丙转氨酶(<0.001)也具有显著性。

结论

我们的研究结果表明,NLR与DN之间存在显著关系。因此,NLR可被视为DN早期阶段的一种新型替代标志物。

相似文献

1
Study of Neutrophil-lymphocyte Ratio as Novel Marker for Diabetic Nephropathy in Type 2 Diabetes.
Indian J Endocrinol Metab. 2017 May-Jun;21(3):387-392. doi: 10.4103/ijem.IJEM_476_16.
3
The relationship between neutrophil-to-lymphocyte ratio and albuminuria in type 2 diabetic patients: a pilot study.
Arch Med Sci. 2016 Jun 1;12(3):571-5. doi: 10.5114/aoms.2016.59931. Epub 2016 May 18.
4
Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy.
Clin Endocrinol (Oxf). 2015 Feb;82(2):229-33. doi: 10.1111/cen.12576. Epub 2014 Sep 26.
7
Clinical value of lymphocyte count in autoimmune diabetic nephropathy.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 28;48(11):1639-1649. doi: 10.11817/j.issn.1672-7347.2023.230110.
8
Association of neutrophil-to-lymphocyte ratio with early renal dysfunction and albuminuria among diabetic patients.
Int Urol Nephrol. 2019 Mar;51(3):483-490. doi: 10.1007/s11255-018-02065-2. Epub 2019 Jan 3.
9
Effects of neutrophil-lymphocyte ratio on renal function and histologic lesions in patients with diabetic nephropathy.
Nephrology (Carlton). 2019 Nov;24(11):1115-1121. doi: 10.1111/nep.13517. Epub 2019 Apr 29.

引用本文的文献

1
Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis.
Front Endocrinol (Lausanne). 2025 Aug 18;16:1532682. doi: 10.3389/fendo.2025.1532682. eCollection 2025.
4
Association between neutrophil-to-lymphocyte ratio and diabetic retinopathy in patients with type 2 diabetes: a cohort study.
Front Endocrinol (Lausanne). 2024 Jul 11;15:1396161. doi: 10.3389/fendo.2024.1396161. eCollection 2024.
5
Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients.
World J Clin Cases. 2024 May 16;12(14):2308-2315. doi: 10.12998/wjcc.v12.i14.2308.
7
Clinical value of lymphocyte count in autoimmune diabetic nephropathy.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 28;48(11):1639-1649. doi: 10.11817/j.issn.1672-7347.2023.230110.
9
Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians.
Bioinformation. 2023 Apr 30;19(4):375-379. doi: 10.6026/97320630019375. eCollection 2023.
10

本文引用的文献

1
The relationship between neutrophil-to-lymphocyte ratio and albuminuria in type 2 diabetic patients: a pilot study.
Arch Med Sci. 2016 Jun 1;12(3):571-5. doi: 10.5114/aoms.2016.59931. Epub 2016 May 18.
4
Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy.
Clin Endocrinol (Oxf). 2015 Feb;82(2):229-33. doi: 10.1111/cen.12576. Epub 2014 Sep 26.
5
Chapter 1: Definition and classification of CKD.
Kidney Int Suppl (2011). 2013 Jan;3(1):19-62. doi: 10.1038/kisup.2012.64.
7
Neutrophil-lymphocyte ratio as a new predictive and prognostic factor at the hearing loss of diabetic patients.
Eur Arch Otorhinolaryngol. 2014 Oct;271(10):2681-6. doi: 10.1007/s00405-013-2734-3.
8
Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy.
Diabetes Technol Ther. 2013 Nov;15(11):942-7. doi: 10.1089/dia.2013.0097. Epub 2013 Aug 6.
9
Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients?
J Endocrinol Invest. 2013 Sep;36(8):593-9. doi: 10.3275/8894. Epub 2013 Mar 19.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验