Khandare Sagar Ashokrao, Chittawar Sachin, Nahar Nitin, Dubey T N, Qureshi Zahraan
Department of Medicine, Gandhi Medical College and Hamidia Hospital, Bhopal, Madhya Pradesh, India.
Medical Affairs, Zydus Discovery, Ahmedabad, Gujarat, India.
Indian J Endocrinol Metab. 2017 May-Jun;21(3):387-392. doi: 10.4103/ijem.IJEM_476_16.
Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflammatory marker such as acute myocardial infarction, stroke, and heart failure. In this study, the association of neutrophil-lymphocyte ratio (NLR) with DN is studied.
It is an observational cross-sectional study. Totally 115 diagnosed type 2 diabetes mellitus patients were registered in this study. NLR was calculated by analyzing differential leukocyte count in complete blood picture. Albuminuria was tested by MICRAL-II TEST strips by dipstick method.
Totally 115 diabetic patients were registered. About 56 patients had DN and 59 had normal urine albumin. Mean NLR for a normal group is 1.94 ± 0.65 and in DN group is 2.83 ± 0.85 which was highly significant ( < 0.001). Estimated glomerular filtration rate ( = 0.047) and serum glutamate pyruvate transaminase ( < 0.001) were also significant.
The results of our study show that there was a significant relation between NLR and DN. Therefore, NLR may be considered as a novel surrogate marker of DN in early stages.
糖尿病肾病（DN）是糖尿病的一种微血管并发症。DN的临床表现为尿白蛋白排泄增加。白细胞总数是一种粗略但敏感的炎症指标，在许多心脏和非心脏疾病中作为炎症标志物进行研究，如急性心肌梗死、中风和心力衰竭。在本研究中，探讨了中性粒细胞与淋巴细胞比值（NLR）与DN的相关性。
这是一项观察性横断面研究。本研究共登记了115例确诊的2型糖尿病患者。通过分析全血细胞计数中的白细胞分类计数来计算NLR。采用尿试纸法用MICRAL-II试纸条检测蛋白尿。
共登记了115例糖尿病患者。约56例患者患有DN，59例尿白蛋白正常。正常组的平均NLR为1.94±0.65，DN组为2.83±0.85，差异具有高度显著性（<0.001）。估计肾小球滤过率（=0.047）和血清谷丙转氨酶（<0.001）也具有显著性。
我们的研究结果表明，NLR与DN之间存在显著关系。因此，NLR可被视为DN早期阶段的一种新型替代标志物。
