Mahajan Mayank, Prasad Manoj Kumar, Ashok Chanchal, Guria Rishi Tuhin, Marandi Sujeet, Subrat Sudhanshu, Chowdhury Anindya
Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
Internal Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
Cureus. 2023 Sep 3;15(9):e44601. doi: 10.7759/cureus.44601. eCollection 2023 Sep.
Background High neutrophil-to-lymphocyte ratio (NLR) may be used as a reliable measure of vascular complications and an indicator of poor outcomes in cases of diabetes mellitus (DM). Methods A prospective analytical cross-sectional observational study was conducted at the Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India. A total of 100 patients with DM who met the inclusion and exclusion criteria were included in the study. A pre-tested and semi-structured questionnaire was given to the patients. IBM SPSS software version 26 (IBM Corp., Armonk, NY, USA) and MedCalc trial version 20.114 (MedCalc Software Ltd., Ostend, Belgium) were used for data analysis. Logistic regression analysis was performed to determine the association of the NLR with microvascular complications. Results In our study, the male-to-female ratio was 1.78:1 (male: 64 (n)%, female: 36 (n)%). The mean age of our study population was 56.28 ± 13.24 years. Of 58 patients with microvascular complications, 34 had a high NLR, and 24 patients had a normal NLR. Of 42 patients without microvascular complications, only 14 had a high NLR, and the remaining 28 patients had a normal NLR (p = 0.012). Logistic regression was performed to analyze the association between the NLR and microvascular complications, which demonstrated a significant association (odds ratio (OR): 2.833, 95% confidence interval (CI): 1.238-6.481; p = 0.013). Conclusions Our study demonstrated the higher odds of having microvascular complications among diabetics with a high NLR compared with non-diabetics. Therefore, the NLR may be used as a measure of microvascular complications in the diabetic population.
背景 高中性粒细胞与淋巴细胞比值（NLR）可作为糖尿病（DM）患者血管并发症的可靠指标及预后不良的一项指征。方法 在印度贾坎德邦兰契市的拉金德拉医学科学研究所（RIMS）开展了一项前瞻性分析性横断面观察研究。共有100例符合纳入和排除标准的糖尿病患者纳入本研究。向患者发放了经过预测试的半结构化问卷。使用IBM SPSS软件版本26（美国纽约州阿蒙克市IBM公司）和MedCalc试用版本20.114（比利时奥斯坦德市MedCalc软件有限公司）进行数据分析。进行逻辑回归分析以确定NLR与微血管并发症之间的关联。结果 在我们的研究中，男女比例为1.78:1（男性：64例（n）%，女性：36例（n）%）。我们研究人群的平均年龄为56.28±13.24岁。在58例有微血管并发症的患者中，34例NLR高，24例NLR正常。在42例无微血管并发症的患者中，只有14例NLR高，其余28例患者NLR正常（p = 0.012）。进行逻辑回归分析NLR与微血管并发症之间的关联，结果显示存在显著关联（比值比（OR）：2.833，95%置信区间（CI）：1.238 - 6.481；p = 0.013）。结论 我们的研究表明，与NLR正常的糖尿病患者相比，NLR高的糖尿病患者发生微血管并发症的几率更高。因此，NLR可作为糖尿病患者微血管并发症的一项指标。
