Odusan Olatunde O, Familoni Oluranti Babatope, Odewabi Adesina O, Idowu Akolade O, Adekolade Ayodeji S
Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
Department of Chemical Pathology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
Indian J Endocrinol Metab. 2017 May-Jun;21(3):439-442. doi: 10.4103/ijem.IJEM_190_16.
Magnesium (Mg) is the 4 most common mineral and the 2 most abundant intracellular cation in the body. It plays major roles in various physiological activities and has been implicated in many disease states.
The aim of this study was to study the patterns and correlates of serum Mg in cohorts of type 2 diabetic patients in Nigeria.
One hundred and twenty-five patients comprising 63 with type 2 diabetes mellitus (T2DM) alone and 62 with diabetes and hypertension (HT) were compared with fifty controls matched for sex and age. Basic data, HbA1c, and fasting blood glucose (FBG) were obtained while serum Mg was measured by colorimeter. Relationship between serum Mg and glucose control was considered while serum Mg < 1.6 mg/dl was considered as hypomagnesemia.
The mean serum Mg of all patients was 2.06 ± 0.49 mg/dl, not statistically different from controls at 2.22 ± 0.48 mg/dl. About ¼ (23.2%) of the patients had hypomagnesemia which was significantly more than 12% of controls. Although the patients with diabetes and HT were older and more of females than those with DM alone, the mean serum Mg was comparable (2.03 ± 0.49 vs. 2.09 + 0.50 mg/dl). Twenty-seven percent (27%) of patients who had DM alone was more than 19.3% with HT and diabetes combined. Whereas the FBG was comparable in patients with hypomagnesemia and normal serum Mg, HbA1c was significantly higher in the hypomagnesemia group (8.39 ± 0.98 vs. 6.75 ± 1.22%, = 0.021).
Hypomagnesemia is common in T2DM outpatients occurring approximately one in four patients. It is associated with poor long-term control.
镁（Mg）是体内第四常见的矿物质，也是细胞内含量第二丰富的阳离子。它在各种生理活动中发挥着重要作用，并与多种疾病状态有关。
本研究旨在探讨尼日利亚2型糖尿病患者队列中血清镁的模式及其相关因素。
将125例患者（其中63例仅患有2型糖尿病（T2DM），62例患有糖尿病和高血压（HT））与50例年龄和性别匹配的对照者进行比较。收集基本数据、糖化血红蛋白（HbA1c）和空腹血糖（FBG），同时用比色计测量血清镁。考虑血清镁与血糖控制之间的关系，血清镁<1.6mg/dl被视为低镁血症。
所有患者的平均血清镁为2.06±0.49mg/dl，与对照组的2.22±0.48mg/dl无统计学差异。约四分之一（23.2%）的患者患有低镁血症，显著高于对照组的12%。虽然患有糖尿病和高血压的患者比仅患有糖尿病的患者年龄更大且女性更多，但平均血清镁相当（2.03±0.49 vs. 2.09 + 0.50mg/dl）。仅患有糖尿病的患者中有27%，高于糖尿病合并高血压患者的19.3%。低镁血症患者和血清镁正常的患者空腹血糖相当，但低镁血症组的糖化血红蛋白显著更高（8.39±0.98 vs. 6.75±1.22%，P = 0.021）。
低镁血症在2型糖尿病门诊患者中很常见，约四分之一的患者会出现。它与长期控制不佳有关。
