Lal J, Vasudev Kamini, Kela A K, Jain S K
Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, 110 001.
J Assoc Physicians India. 2003 Jan;51:37-42.
Controversial reports are available regarding the effect of magnesium (Mg) on lipid profile and glycaemic control in diabetic patients. The present study was designed on 1) compare serum Mg levels in diabetic patients with those of non-diabetic controls and 2) to assess the effect of oral Mg supplementation on lipid profile and blood glucose of these patients.
The study included 40 patients of type 2 diabetes mellitus (DM) and 54 age and sex matched non-diabetic controls. After the baseline investigations of all the subjects (n=94) including blood glucose, serum lipid and magnesium, the diabetic patients (study group) were supplemented with 600 mg of Mg oxide daily for 12 weeks. They were followed up every four weeks (for a total duration of twelve weeks) and investigated for the above parameters.
Mean serum magnesium at baseline in the diabetic patients was significantly lower than that in controls (1.44 +/- 0.48 mg/dl Vs 2.29 +/- 0.33 mg/dl; p < 0.001). A significant fall in serum total cholesterol, LDL cholesterol and triglycerides and a rise in HDL cholesterol levels was observed 4 to 8 weeks after initiation of magnesium supplementation and continued till the end of the study i.e. 12 weeks. Fasting and post-prandial blood glucose levels did not show any significant change after twelve weeks of magnesium supplementation when compared with baseline.
A significant hypomagnesemia was observed in diabetic patients as compared to controls and Mg supplementation resulted in a beneficial effect on the lipid profile of these patients with no significant effect on blood glucose levels.
关于镁（Mg）对糖尿病患者血脂和血糖控制的影响，存在相互矛盾的报道。本研究旨在：1）比较糖尿病患者与非糖尿病对照者的血清镁水平；2）评估口服补充镁对这些患者血脂和血糖的影响。
本研究纳入40例2型糖尿病（DM）患者和54例年龄及性别匹配的非糖尿病对照者。在对所有受试者（n = 94）进行包括血糖、血脂和镁在内的基线检查后，糖尿病患者（研究组）每天补充600 mg氧化镁，持续12周。每四周对他们进行随访（总共持续12周），并对上述参数进行检测。
糖尿病患者基线时的平均血清镁水平显著低于对照组（1.44±0.48 mg/dl对2.29±0.33 mg/dl；p < 0.001）。在开始补充镁后4至8周，观察到血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯显著下降，高密度脂蛋白胆固醇水平升高，并持续到研究结束，即12周。与基线相比，补充镁12周后空腹和餐后血糖水平未显示出任何显著变化。
与对照组相比，糖尿病患者中观察到显著的低镁血症，补充镁对这些患者的血脂有有益影响，对血糖水平无显著影响。
