a Department of Biotechnology , Bharathidasan University , Tiruchirappalli , India.
b Department of Biotechnology , Mizoram University , Aizawl , India.
Artif Cells Nanomed Biotechnol. 2018 May;46(3):589-598. doi: 10.1080/21691401.2017.1332635. Epub 2017 May 29.
In the present study, a sustainable green chemistry approach was established to fabricate magnetic FeO nanoparticles (FeONPs) using the aqueous fruit extract of edible C. guianensis (CGFE). Synthesized NPs were further confirmed with different high-throughput characterization techniques such as UV-visible spectroscopy, FT-IR, XPS, DLS and zeta potential analysis. Additionally, XRD, AFM, HRTEM and SQUID VSM demonstrate the generation of crystalline CGFeONPs with mean diameter of 17 ± 10 nm. Interestingly, CGFeONPs exhibit a stupendous bactericidal action against different human pathogens which depicts its antimicrobial value. A significant dose-dependent cytotoxic effect of CGFeONPs was noticed against treated human hepatocellular carcinoma cells (HepG2).
在本研究中，建立了一种可持续的绿色化学方法，使用食用可可（C. guianensis）的水提水果提取物来制备磁性 FeO 纳米颗粒（FeONPs）。合成的 NPs 进一步通过不同的高通量表征技术进行了确认，例如 UV-可见光谱、FT-IR、XPS、DLS 和 ζ 电位分析。此外，XRD、AFM、HRTEM 和 SQUID VSM 表明生成了具有平均直径为 17±10nm 的结晶性 CGFeONPs。有趣的是，CGFeONPs 对不同的人类病原体表现出了惊人的杀菌作用，显示出其抗菌价值。对经 CGFeONPs 处理的人肝癌细胞（HepG2）的细胞毒性作用具有显著的剂量依赖性。
