Yang Yuan, Wen Yunhong, Bedi Carolyn, Humphris Gerry
Department of Psychiatry and Psychology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China.
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
J Psychosom Res. 2017 Jul;98:55-63. doi: 10.1016/j.jpsychores.2017.05.002. Epub 2017 May 3.
The study aim was to provide an overview of the current evidence available on the link between chemotherapy (CTX) and fear of cancer recurrence (FoR).
PubMED, Medline, Embase, PsycINFO and Web of Science databases were searched to identify relevant studies. Two authors independently selected and assessed the studies regarding eligibility criteria. Meta-analysis of suitable studies was conducted, and quality rated.
Forty eligible studies were included in the systematic review and twenty-nine of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between CTX and FoR (29 studies, 30,176 patients, overall r=0.093, 95% CI: 0.062, 0.123, P˂0.001).
The meta-analysis demonstrates a weak but significant relationship between cancer patient's FoR and the receipt of chemotherapy. However, these results should be interpreted with caution. Further investigation is warranted to explore possible mechanisms of FoR increase in patients who receive chemotherapy. Longitudinal studies assessing the trajectory of FoR during chemotherapy are also warranted.
本研究旨在概述目前关于化疗（CTX）与癌症复发恐惧（FoR）之间联系的现有证据。
检索了PubMed、Medline、Embase、PsycINFO和科学网数据库以识别相关研究。两位作者独立选择并评估了符合纳入标准的研究。对合适的研究进行了荟萃分析，并对质量进行了评级。
系统评价纳入了40项符合条件的研究，其中29项纳入了进一步的荟萃分析。对现有数据的荟萃分析证实，CTX与FoR之间存在弱相关性（29项研究，30176例患者，总体r = 0.093，95%CI：0.062，0.123，P˂0.001）。
荟萃分析表明癌症患者的FoR与接受化疗之间存在微弱但显著的关系。然而，这些结果应谨慎解释。有必要进一步研究以探索接受化疗患者FoR增加的可能机制。也有必要进行纵向研究以评估化疗期间FoR的变化轨迹。
