Homayouni Maryam, Mohammad Arabzadeh Seyed Ali, Nili Fatemeh, Razi Farideh, Amoli Mahsa Mohammad
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Virology, Kerman University of Medical Sciences, Kerman, Iran.
Department of Medical Virology, Kerman University of Medical Sciences, Kerman, Iran.
Pathol Res Pract. 2017 Jul;213(7):854-856. doi: 10.1016/j.prp.2017.01.020. Epub 2017 Jan 28.
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. EBV is one of the most important viruses related to different types of malignancies. This study investigated the relationship between EBV and papillary thyroid carcinoma.
In this study the presence of Epstein-Barr Nuclear Antigen 1 (EBNA1) gene in papillary thyroid carcinoma tissues were examined by nested-PCR method. Paraffin-embedded tissues (N=41) blocks of thyroid cancer were used. DNA was extracted from all samples and then samples were evaluated for the presence of EBV gene.
In 41 samples, EBNA1 was detected in 65.8% of patients with papillary thyroid carcinoma which was significantly higher in younger ages.
The significant presence of EBV genome in papillary thyroid carcinoma suggests that this virus may play a role in this cancer especially in younger ages. As a result, monitoring of patients with EBV latent infection for PTC can be very important.
甲状腺乳头状癌（PTC）是最常见的甲状腺癌。EB病毒是与不同类型恶性肿瘤相关的最重要病毒之一。本研究调查了EB病毒与甲状腺乳头状癌之间的关系。
在本研究中，采用巢式PCR法检测甲状腺乳头状癌组织中EB病毒核抗原1（EBNA1）基因的存在情况。使用了41个甲状腺癌石蜡包埋组织块。从所有样本中提取DNA，然后评估样本中EB病毒基因的存在情况。
在41个样本中，65.8%的甲状腺乳头状癌患者检测到EBNA1，在较年轻患者中显著更高。
EB病毒基因组在甲状腺乳头状癌中的显著存在表明该病毒可能在这种癌症中起作用，尤其是在较年轻患者中。因此，对EB病毒潜伏感染患者进行甲状腺乳头状癌监测可能非常重要。
