Ho Thu Huong, Guillon François-Xavier, Bigey Pascal, Bedioui Fethi, Lazerges Mathieu
Unité de Technologies Chimiques et Biologiques pour la Santé, U 1022 INSERM, UMR 8258 CNRS. PSL Research University, Chimie ParisTech. Sorbonne Paris Cité, Université Paris Descartes, Faculté de Pharmacie de Paris, Paris, France.
Anal Bioanal Chem. 2017 Jul;409(18):4335-4352. doi: 10.1007/s00216-017-0377-8. Epub 2017 May 29.
This critical review of electrochemical biosensors allowing direct detection of nucleic acid targets reports on different transduction pathways and their latest breakthroughs. A classification of the various strategies based on the nature of the electrochemical transduction is established to emphasize the efficiency of each of them. It provides an overall picture of the detection limit of the various approaches developed during the last two decades. Graphical Abstract Detection limits evolutions of electrochemical DNA biosensors.
这篇对可直接检测核酸靶标的电化学生物传感器的批判性综述报告了不同的转导途径及其最新突破。基于电化学转导的性质对各种策略进行了分类，以强调每种策略的效率。它提供了过去二十年中所开发的各种方法的检测限的总体情况。图形摘要：电化学生物传感器的检测限演变。
