Xue Fengfeng, Wen Ying, Wei Peng, Gao Yilin, Zhou Zhiguo, Xiao Shuzhang, Yi Tao
Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, China.
Chem Commun (Camb). 2017 Jun 13;53(48):6424-6427. doi: 10.1039/c7cc03168h.
We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nanoparticles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.
我们报道了一种基于花菁染料的用于光热疗法（PTT）的pH响应型光热消融剂（pH-PTT）。与正常细胞相比，由牛血清白蛋白（BSA）和pH-PTT形成的纳米颗粒优先积聚在癌细胞的高尔基体中，因此可以被癌细胞中酸性的高尔基体特异性激活，从而在体外和体内实现有效的光热疗法。
