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通过白蛋白增溶的光稳定近红外吸收双自由基铂（II）配合物，用于癌症光热治疗剂。

Photostable near-infrared-absorbing diradical-platinum(ii) complex solubilized by albumin toward a cancer photothermal therapy agent.

作者信息

Sawamura Ryota, Sato Masataka, Masuya-Suzuki Atsuko, Iki Nobuhiko

机构信息

Graduate School of Environmental Studies, Tohoku University 6-6-07, Aramaki-Aoba, Aoba-ku Sendai 980-8579 Japan

出版信息

RSC Adv. 2020 Feb 11;10(11):6460-6463. doi: 10.1039/d0ra00652a. eCollection 2020 Feb 7.

DOI:10.1039/d0ra00652a
PMID:35496030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9049767/
Abstract

A hydrophobic diradical-platinum(ii) complex was solubilized in aqueous solutions by using bovine serum albumin and exhibited photothermal conversion under near-infrared (NIR) light irradiation. The complex was introduced into cancer cells and induced cell death upon absorption of NIR. These results imply that the complex can function as a photothermal therapeutic agent.

摘要

一种疏水性双自由基铂（II）配合物通过使用牛血清白蛋白溶解于水溶液中，并在近红外（NIR）光照射下表现出光热转换。该配合物被引入癌细胞中，并在吸收近红外光后诱导细胞死亡。这些结果表明该配合物可作为一种光热治疗剂发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/8282d8503569/d0ra00652a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/a84da76b6418/d0ra00652a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/42c05b1591d7/d0ra00652a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/1cc85f3759bc/d0ra00652a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/d2cdec630197/d0ra00652a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/8282d8503569/d0ra00652a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/a84da76b6418/d0ra00652a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/42c05b1591d7/d0ra00652a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/1cc85f3759bc/d0ra00652a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/d2cdec630197/d0ra00652a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea4/9049767/8282d8503569/d0ra00652a-f4.jpg

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