Institut für Organische und Biomolekulare Chemie, Georg-August-Universität , Tammannstraße 2, 37077 Göttingen, Germany.
Org Lett. 2017 Jun 16;19(12):3171-3174. doi: 10.1021/acs.orglett.7b01294. Epub 2017 May 30.
C-H alkynylations with weakly coordinating acids were accomplished by the aid of an expedient ruthenium(II) catalysis manifold. The user-friendly C-H alkynylation occurred under mild conditions with the weak base KCO. The versatility of the ruthenium(II) catalysis was reflected by providing step-economical access to phthalides as well as enabling unprecedented decarboxylative ortho-C-H alkynylations.
弱配位酸促进的 C-H 炔基化反应是通过一种简便的钌（II）催化多相反应来实现的。在温和条件下，使用弱碱 KCO，用户友好的 C-H 炔基化反应得以发生。钌（II）催化的多功能性体现在以经济有效的方式合成邻位 C-H 炔基取代的苯酞以及实现前所未有的脱羧基邻位 C-H 炔基化反应。
