Zinn Kai, Özkan Engin
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, United States.
Curr Opin Neurobiol. 2017 Aug;45:99-105. doi: 10.1016/j.conb.2017.05.010. Epub 2017 May 27.
The immunoglobulin superfamily (IgSF) encompasses hundreds of cell surface proteins containing multiple immunoglobulin-like (Ig) domains. Among these are neural IgCAMs, which are cell adhesion molecules that mediate interactions between cells in the nervous system. IgCAMs in some vertebrate IgSF subfamilies bind to each other homophilically and heterophilically, forming small interaction networks. In Drosophila, a global 'interactome' screen identified two larger networks in which proteins in one IgSF subfamily selectively interact with proteins in a different subfamily. One of these networks, the 'Dpr-ome', includes 30 IgSF proteins, each of which is expressed in a unique subset of neurons. Recent evidence shows that one interacting protein pair within the Dpr-ome network is required for development of the brain and neuromuscular system.
免疫球蛋白超家族（IgSF）包含数百种含有多个免疫球蛋白样（Ig）结构域的细胞表面蛋白。其中包括神经IgCAMs，它们是介导神经系统中细胞间相互作用的细胞粘附分子。一些脊椎动物IgSF亚家族中的IgCAMs通过同源和异源方式相互结合，形成小的相互作用网络。在果蝇中，一项全面的“相互作用组”筛选确定了两个更大的网络，其中一个IgSF亚家族中的蛋白质与另一个不同亚家族中的蛋白质选择性相互作用。其中一个网络，即“Dpr组”，包括30种IgSF蛋白，每种蛋白都在独特的神经元亚群中表达。最近的证据表明，Dpr组网络中的一对相互作用蛋白是大脑和神经肌肉系统发育所必需的。
