Fu Meng, Fu Shulian, Ni Saihong, Zou Liyuan, Liu Yumei, Hong Tie
Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China.
China-Japan Union Hospital of Jilin University, Changchun 130021, China.
Int Immunopharmacol. 2017 Aug;49:102-108. doi: 10.1016/j.intimp.2017.05.030. Epub 2017 May 27.
Currently, a variety of studies have demonstrated that green tea has anti-allergic properties, and the major polyphenolic compound, epigallocatechin gallate (EGCG), plays a significant role. Some research indicates that EGCG reduces the production and expression of allergy-related substances. Therefore, EGCG has a potential effect of reducing allergic rhinitis (AR). In this study, the effect of EGCG on allergic rhinitis in an ovalbumin (OVA)-induced mouse model was investigated. After administration of EGCG, the number of sneezes and the occurrence of nasal rubbing were significantly decreased, the concentrations of immunoglobulin E (IgE) and histamine were suppressed in AR mouse serum, the levels of interleukin (IL)-1β, IL-4, and IL-6 were reduced in AR mice nasal lavage fluid (NLF), and the nasal mucosa mRNA and protein expression of cyclooxygenase 2 (COX-2), IL-1β, IL-4, and IL-6 were inhibited. The data indicate that EGCG has a beneficial effect of reducing allergic rhinitis.
目前，多项研究表明绿茶具有抗过敏特性，其中主要的多酚类化合物表没食子儿茶素没食子酸酯（EGCG）发挥着重要作用。一些研究表明，EGCG可减少过敏相关物质的产生和表达。因此，EGCG具有减轻变应性鼻炎（AR）的潜在作用。在本研究中，我们调查了EGCG对卵清蛋白（OVA）诱导的小鼠变应性鼻炎模型的影响。给予EGCG后，小鼠的喷嚏次数和鼻痒发作次数显著减少，AR小鼠血清中免疫球蛋白E（IgE）和组胺的浓度受到抑制，AR小鼠鼻灌洗液（NLF）中白细胞介素（IL）-1β、IL-4和IL-6的水平降低，鼻黏膜中环氧合酶2（COX-2）、IL-1β、IL-4和IL-6的mRNA和蛋白表达受到抑制。数据表明，EGCG具有减轻变应性鼻炎的有益作用。
