Jutagir Devika R, Blomberg Bonnie B, Carver Charles S, Lechner Suzanne C, Timpano Kiara R, Bouchard Laura C, Gudenkauf Lisa M, Jacobs Jamie M, Diaz Alain, Lutgendorf Susan K, Cole Steve W, Heller Aaron S, Antoni Michael H
Department of Psychology, University of Miami, 5665 Ponce De Leon Blvd., Coral Gables, FL, 33146, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
Breast Cancer Res Treat. 2017 Aug;165(1):169-180. doi: 10.1007/s10549-017-4316-3. Epub 2017 May 30.
Satisfaction with social resources, or "social well-being," relates to better adaptation and longer survival after breast cancer diagnosis. Biobehavioral mechanisms linking social well-being (SWB) to mental and physical health may involve inflammatory signaling. We tested whether reports of greater SWB were associated with lower levels of pro-inflammatory and pro-metastatic leukocyte gene expression after surgery for non-metastatic breast cancer.
Women (N = 50) diagnosed with non-metastatic (0-III) breast cancer were enrolled 2-8 weeks after surgery. SWB was assessed with the social/family well-being subscale of the FACT-B. Leukocyte gene expression for specific pro-inflammatory (cytokines, chemokines, and COX-2) and pro-metastatic genes (e.g., MMP9) was derived from microarray analysis.
Multiple regression analyses controlling for age, stage of disease, days since surgery, education, and body mass index (BMI) found higher levels of SWB related to less leukocyte pro-inflammatory and pro-metastatic gene expression (p < 0.05). Emotional well-being, physical well-being, and functional well-being did not relate to leukocyte gene expression (p > 0.05). Greater SWB remained significantly associated with less leukocyte pro-inflammatory and pro-metastatic gene expression after controlling for depressive symptoms.
Results have implications for understanding mechanisms linking social resources to health-relevant biological processes in breast cancer patients undergoing primary treatment.
NCT01422551.
对社会资源的满意度，即“社会幸福感”，与乳腺癌诊断后的更好适应和更长生存期相关。将社会幸福感（SWB）与心理和身体健康联系起来的生物行为机制可能涉及炎症信号传导。我们测试了在非转移性乳腺癌手术后，较高的SWB报告是否与较低水平的促炎和促转移白细胞基因表达相关。
对诊断为非转移性（0-III期）乳腺癌的女性（N = 50）在术后2-8周进行入组。使用FACT-B的社会/家庭幸福感子量表评估SWB。通过微阵列分析得出特定促炎基因（细胞因子、趋化因子和COX-2）和促转移基因（如MMP9）的白细胞基因表达。
在控制年龄、疾病分期、术后天数、教育程度和体重指数（BMI）的多元回归分析中发现，较高水平的SWB与较少的白细胞促炎和促转移基因表达相关（p < 0.05）。情绪幸福感、身体幸福感和功能幸福感与白细胞基因表达无关（p > 0.05）。在控制抑郁症状后，较高的SWB仍与较少的白细胞促炎和促转移基因表达显著相关。
研究结果对于理解在接受初级治疗的乳腺癌患者中，将社会资源与健康相关生物过程联系起来的机制具有启示意义。
NCT01422551。
