Wu Shan Shan, Abraham Tina, Michaud Chelsea, Peppers Brian, Ward Andrea, Buchner Stacey Ehrenberg, Teba Catalina V, Tcheurekdjian Haig, Hostoffer Robert, Jhaveri Devi
a Internal Medicine Residency Program , University Hospitals Regional Hospitals , Richmond Heights , OH , USA.
b Allergy/Immunology Fellowship Program , University Hospitals Cleveland Medical Center , Cleveland , OH , USA.
J Matern Fetal Neonatal Med. 2018 Aug;31(16):2223-2225. doi: 10.1080/14767058.2017.1336221. Epub 2017 Jun 20.
Penicillin desensitization is indicated in pregnant patients with severe allergies to penicillin with syphilis. The immediate effects of intramuscular epinephrine on the fetus during desensitization remain unreported. We describe a pregnant patient with secondary syphilis and penicillin allergy who developed anaphylaxis during penicillin desensitization. Anaphylaxis resolved after administration of intramuscular epinephrine. Throughout the procedure, continuous electronic fetal monitoring showed a stable fetus without a decrease in variability, tachycardia, decelerations, or signs of fetal distress. This case showed that intramuscular epinephrine is effective in treatment of anaphylaxis in a pregnant patient with little to no immediate effects on the fetus.
对于患有梅毒且对青霉素严重过敏的孕妇，需进行青霉素脱敏治疗。目前尚无关于脱敏过程中肌肉注射肾上腺素对胎儿的即时影响的报道。我们描述了一名患有二期梅毒且对青霉素过敏的孕妇，她在青霉素脱敏过程中发生了过敏反应。肌肉注射肾上腺素后过敏反应得到缓解。在整个过程中，连续电子胎儿监护显示胎儿情况稳定，无变异减少、心动过速、减速或胎儿窘迫迹象。该病例表明，肌肉注射肾上腺素对治疗孕妇过敏反应有效，且对胎儿几乎没有即时影响。
