Hutchings D E, Fico T A, Banks A N, Dick L S, Brake S C
New York State Psychiatric Institute, Department of Developmental Psychobiology, NY 10032.
Neurotoxicol Teratol. 1991 Mar-Apr;13(2):245-8. doi: 10.1016/0892-0362(91)90018-r.
Either 15 or 30 mg/kg of delta-9-tetrahydrocannabinol (delta-9-THC) was administered from Day 2 through Day 22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. When weighed at 57-60 days of age, pair-fed controls were significantly heavier than the nontreated, whereas the treated animals were intermediate between the controls. These findings are discussed with respect to nutritional studies that have reported postnatal growth enhancement following prenatal maternal undernutrition and the possibility that prenatal delta-9-THC inhibits this effect.
在妊娠第2天至第22天期间，给予15或30毫克/千克的δ-9-四氢大麻酚（δ-9-THC）。配对喂养组和未处理组作为对照组，所有处理组和对照组的幼崽在出生时寄养给未处理的母鼠。在57至60日龄称重时，配对喂养的对照组明显比未处理组重，而处理组动物的体重介于两组对照组之间。结合营养研究讨论了这些发现，这些研究报告了产前母体营养不良后出生后生长增强的情况，以及产前δ-9-THC抑制这种效应的可能性。
