Limson B M, Navarro-Almario E, Litam P, Que E, Kua L T
Philippine Heart Center for Asia, University of the Philippines, Quezon City.
Clin Ther. 1988;10(5):589-93.
Hospital patients with severe gram-negative bacterial infections were randomly assigned to treatment with ceftazidime (2 gm every eight or 12 hours) or a combination of amikacin (500 mg every 12 hours) and ticarcillin (3 gm every six or eight hours). The clinical and bacteriological responses to treatment were satisfactory in most of the patients in both treatment groups. Clinical cure was achieved in 18 of the 20 patients treated with ceftazidime and in 17 of the 20 treated with amikacin-ticarcillin. The bacterial eradication rate was 19 of 21 pathogens in the ceftazidime group and 17 of 20 pathogens in the amikacin-ticarcillin group.
患有严重革兰氏阴性菌感染的住院患者被随机分配接受头孢他啶治疗（每8或12小时2克）或阿米卡星（每12小时500毫克）与替卡西林（每6或8小时3克）联合治疗。两个治疗组中的大多数患者对治疗的临床和细菌学反应都令人满意。接受头孢他啶治疗的20名患者中有18名实现了临床治愈，接受阿米卡星-替卡西林治疗的20名患者中有17名实现了临床治愈。头孢他啶组21种病原体中的19种细菌清除率，以及阿米卡星-替卡西林组20种病原体中的17种细菌清除率。
