Lassus A, Nolting K S, Savopoulos C
University Central Hospital, Helsinki, Finland.
Clin Ther. 1988;10(5):594-9.
The hydroxypyridone antifungal agent ciclopirox olamine cream 1% has been shown to be as effective in the treatment of inflamed, superficial fungal infections as a formulation in which ciclopirox 1% and hydrocortisone acetate 1% were combined. In a randomized, double-blind, parallel group comparison study, 138 patients with culture-confirmed superficial fungal diseases applied their assigned medication twice daily for 21 days. Clinical assessments were made at the baseline visit; at visits on days 4, 7, 14, and 21 during treatment; and on day 28 (one week posttreatment). Specimens for cultures were taken at baseline and on day 28. There were no differences for the 69 patients in either treatment group at any visit with respect to improvement in the signs/symptoms evaluated; mycological cures in the two treatment groups also were not significantly different.
1%的羟基吡啶酮抗真菌剂环吡酮胺乳膏已被证明在治疗炎症性浅表真菌感染方面与1%环吡酮和1%醋酸氢化可的松联合制剂一样有效。在一项随机、双盲、平行组对照研究中，138例经培养确诊为浅表真菌病的患者每天两次使用分配给他们的药物，持续21天。在基线访视时、治疗期间第4、7、14和21天的访视时以及第28天（治疗后一周）进行临床评估。在基线和第28天采集培养标本。在任何一次访视中，两个治疗组的69例患者在评估的体征/症状改善方面均无差异；两个治疗组的真菌学治愈率也无显著差异。
