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斯托克斯提取物对光老化小鼠皮肤的影响。

The Effect of Stokes Extracts on Photo-Aged Mouse Skin.

作者信息

Hong Hannah, Jung Minyoung, Choe Sung Jay, Kim Jung-Bae, Choi Eung Ho

机构信息

Depatment of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Department of Food and Nutrition, Sangji Youngseo College, Wonju, Korea.

出版信息

Ann Dermatol. 2017 Jun;29(3):295-301. doi: 10.5021/ad.2017.29.3.295. Epub 2017 May 11.

DOI:10.5021/ad.2017.29.3.295
PMID:28566905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438935/
Abstract

BACKGROUND

Stokes (RV) has traditionally been used in Korea as an indigenous food (Rhus chicken soup) and as an herbal medicinal plant. While the anticancer, antimicrobial, and anti-inflammatory properties of RV have been actively studied in the medical field, its antioxidant effects in the skin that resist the reactive oxygen species in keratinocytes and fibroblasts is less understood.

OBJECTIVE

We designed to evaluate the effects of Stokes extract (RVE) on the photo-aged skin by an experiment using human fibroblasts and an experiment using a photo-aged murine model.

METHODS

For the experiments, human fibroblasts irradiated with ultraviolet (UV) B were treated with RVE or vehicle, and the growth levels and the expression level of type 1 procollagen were compared. For the experiment, photo-aged mice irradiated with UVB and UVA were administered drinking water with or without RVE, and histological changes and the expression level of type 1 procollagen and matrix metalloprotease (MMP)-13 were compared.

RESULTS

experiments using fibroblasts irradiated with UVB showed that RVE promoted growth and significantly increased the expression of type 1 procollagen as compared to the control group. In the photo-aged mice, RVE increased collagen content in the dermis and promoted the synthesis of type 1 procollagen without any visible decrease in MMP-13 as compared to control group.

CONCLUSION

In addition to the previously reported antioxidant effects of RVE, oral intake of RVE effectively inhibited photo-aging in hairless mice by enhancing collagen synthesis.

摘要

背景

在韩国，光叶石楠（RV）传统上一直被用作本土食物（光叶石楠鸡汤）和草药。虽然RV的抗癌、抗菌和抗炎特性在医学领域已得到积极研究，但其在皮肤中抵抗角质形成细胞和成纤维细胞中活性氧的抗氧化作用却鲜为人知。

目的

我们旨在通过用人成纤维细胞进行的实验和用光老化小鼠模型进行的实验来评估光叶石楠提取物（RVE）对光老化皮肤的影响。

方法

在实验中，用RVE或赋形剂处理经紫外线（UV）B照射的人成纤维细胞，并比较其生长水平和I型前胶原的表达水平。在实验中，给经UVB和UVA照射的光老化小鼠饮用含或不含RVE的水，并比较组织学变化以及I型前胶原和基质金属蛋白酶（MMP）-13的表达水平。

结果

用人成纤维细胞进行的实验表明，与对照组相比，RVE促进了细胞生长并显著增加了I型前胶原的表达。在光老化小鼠中，与对照组相比，RVE增加了真皮中的胶原蛋白含量，促进了I型前胶原的合成，且MMP-13没有明显下降。

结论

除了先前报道的RVE的抗氧化作用外，口服RVE通过增强胶原蛋白合成有效抑制了无毛小鼠的光老化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/6ae458fff630/ad-29-295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/b2f3ad8bccfa/ad-29-295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/90995e9136b0/ad-29-295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/9f1367fbcb9d/ad-29-295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/6ae458fff630/ad-29-295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/b2f3ad8bccfa/ad-29-295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/90995e9136b0/ad-29-295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/9f1367fbcb9d/ad-29-295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bf0/5438935/6ae458fff630/ad-29-295-g004.jpg

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