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口服法国滨海松皮提取物（Flavangenol(®)）可改善光老化面部皮肤的临床症状。

Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.

机构信息

Department of Dermatology, Fukuoka University School of Medicine, Fukuoka, Japan.

出版信息

Clin Interv Aging. 2012;7:275-86. doi: 10.2147/CIA.S33165. Epub 2012 Jul 27.

DOI:10.2147/CIA.S33165
PMID:22956863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3426262/
Abstract

BACKGROUND

French maritime pine bark extract (PBE) has gained popularity as a dietary supplement in the treatment of various diseases due to its polyphenol-rich ingredients. Oligometric proanthocyanidins (OPCs), a class of bioflavonoid complexes, are enriched in French maritime PBE and have antioxidant and anti-inflammatory activity. Previous studies have suggested that French maritime PBE helps reduce ultraviolet radiation damage to the skin and may protect human facial skin from symptoms of photoaging. To evaluate the clinical efficacy of French maritime PBE in the improvement of photodamaged facial skin, we conducted a randomized trial of oral supplementation with PBE.

METHODS

One hundred and twelve women with mild to moderate photoaging of the skin were randomized to either a 12-week open trial regimen of 100 mg PBE supplementation once daily or to a parallel-group trial regimen of 40 mg PBE supplementation once daily.

RESULTS

A significant decrease in clinical grading of skin photoaging scores was observed in both time courses of 100 mg daily and 40 mg daily PBE supplementation regimens. A significant reduction in the pigmentation of age spots was also demonstrated utilizing skin color measurements.

CONCLUSION

Clinically significant improvement in photodamaged skin could be achieved with PBE. Our findings confirm the efficacy and safety of PBE.

摘要

背景

由于富含多酚的成分，法国滨海松树皮提取物（PBE）已作为一种膳食补充剂在治疗各种疾病方面广受欢迎。低聚原花青素（OPC）是一种生物类黄酮复合物，富含法国滨海 PBE，具有抗氧化和抗炎活性。先前的研究表明，法国滨海 PBE 有助于减少紫外线辐射对皮肤的损害，并可能保护人体面部皮肤免受光老化症状的影响。为了评估法国滨海 PBE 口服补充剂改善光损伤面部皮肤的临床疗效，我们进行了一项口服 PBE 补充的随机试验。

方法

112 名皮肤有轻度至中度光老化的女性被随机分配到为期 12 周的 100mg PBE 每日一次的开放性试验方案或 40mg PBE 每日一次的平行组试验方案。

结果

在 100mg 每日和 40mg 每日 PBE 补充方案的两个时间过程中，皮肤光老化评分的临床分级均显著下降。皮肤颜色测量也表明老年斑的色素沉着明显减少。

结论

PBE 可实现光损伤皮肤的临床显著改善。我们的研究结果证实了 PBE 的疗效和安全性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/2b39aa2730cf/cia-7-275f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/eef23ec8e9c1/cia-7-275f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/051b9838cbda/cia-7-275f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/af617fe5ebc5/cia-7-275f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/464c63e8e333/cia-7-275f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/035e6d9c307e/cia-7-275f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/2b39aa2730cf/cia-7-275f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/eef23ec8e9c1/cia-7-275f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/051b9838cbda/cia-7-275f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/af617fe5ebc5/cia-7-275f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/464c63e8e333/cia-7-275f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/035e6d9c307e/cia-7-275f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bddd/3426262/2b39aa2730cf/cia-7-275f6.jpg

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