Shin Sungsik, Shin Jung U, Lee Youngin, Chung Woong Youn, Nam Kee-Hyun, Kwon Tae Gwang, Lee Ju Hee
Department of Dermatology, Severance Hospital, Seoul, Korea.
Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Ann Dermatol. 2017 Jun;29(3):314-320. doi: 10.5021/ad.2017.29.3.314. Epub 2017 May 11.
Growth factors play important roles in wound healing. However, the evidence for the effects of growth factors on post-thyroidectomy scars is limited.
We performed a prospective study to assess the preventive and therapeutic effect of a multi-growth factor (MGF)-containing cream on post-thyroidectomy scars.
Twenty-one patients with thyroidectomy scars applied MGF cream twice a day. We assessed the changes in erythema, pigmentation, skin elasticity, and skin hydration status using the erythema index, melanin index, cutometer, and corneometer, respectively. In addition, Vancouver scar scale (VSS) and patient satisfaction were assessed at 10 days after surgery (baseline), 2 weeks, 6 weeks, and 12 weeks after baseline.
The mean total VSS scores were significantly lower at 6 weeks (3.24±1.51 vs. 1.91±1.38) and 12 weeks (3.24±1.51 vs. 1.71±1.59) compared to the baseline. The degree of pigmentation was significantly lower at 12 weeks compared to the baseline, and the skin elasticity, and the skin hydration status were significantly higher at 12 weeks compared to the baseline. Over 85% of the patients were satisfied with the use of MGF cream without any adverse effect.
MGF cream might have additive or supportive effect for scar formation after thyroidectomy.
生长因子在伤口愈合中起重要作用。然而，生长因子对甲状腺切除术后瘢痕影响的证据有限。
我们进行了一项前瞻性研究，以评估含多种生长因子（MGF）的乳膏对甲状腺切除术后瘢痕的预防和治疗效果。
21例有甲状腺切除术后瘢痕的患者每天两次涂抹MGF乳膏。我们分别使用红斑指数、黑色素指数、皮肤弹性测量仪和角质层水合测量仪评估红斑、色素沉着、皮肤弹性和皮肤水合状态的变化。此外，在术后10天（基线）、基线后2周、6周和12周评估温哥华瘢痕量表（VSS）和患者满意度。
与基线相比，6周时（3.24±1.51对1.91±1.38）和12周时（3.24±1.51对1.71±1.59）的平均VSS总分显著降低。与基线相比，12周时色素沉着程度显著降低，12周时皮肤弹性和皮肤水合状态显著高于基线。超过85%的患者对使用MGF乳膏感到满意，且无任何不良反应。
MGF乳膏可能对甲状腺切除术后瘢痕形成具有相加或支持作用。
