壳提取物和油溶性提取物的抗活性
Anti- Activity of Shell and Oil-Soluble Extracts.
作者信息
Han Song Hee, Hur Min Seok, Kim Min Jung, Jung Won Hee, Park Minji, Kim Jeong Hwan, Shin Hong Ju, Choe Yong Beom, Ahn Kyu Joong, Lee Yang Won
机构信息
Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
出版信息
Ann Dermatol. 2017 Jun;29(3):321-326. doi: 10.5021/ad.2017.29.3.321. Epub 2017 May 11.
BACKGROUND
A new shampoo with anti- properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options.
OBJECTIVE
The aim of this study was to obtain susceptibility profiles of and , the most important pathogenic organisms in the development of seborrheic dermatitis, to the plant extracts used in commercial anti-dandruff shampoos.
METHODS
Minimal inhibitory concentrations (MICs) were determined for eight candidate plant extracts and two plant-derived natural products diluted with Leeming and Notman medium to final concentrations of 0.016 to 1 mg/ml.
RESULTS
shell, leaf, and oil-soluble extracts presented relatively low MIC values (≤0.5 mg/ml) against both strains. The shell and oil-soluble extracts demonstrated especially high activity, suggesting their potential use in the treatment of seborrheic dermatitis. The extracts also showed fungistatic activity against other common facultative pathogenic yeasts, and .
CONCLUSION
shell and oil-soluble extracts could potentially be used as active ingredients in anti-seborrheic and anti-dandruff shampoo formulations. They could be helpful for repeated treatments and regular prophylaxis of scalp seborrheic dermatitis.
背景
需要一种从多种植物中提取具有抗菌特性的新型洗发水，为脂溢性皮炎患者提供更多的治疗选择。
目的
本研究旨在了解脂溢性皮炎发病过程中最重要的致病微生物马拉色菌属和球形马拉色菌对市售去屑洗发水中所用植物提取物的敏感性概况。
方法
用利明和诺特曼培养基将8种候选植物提取物和2种植物来源的天然产物稀释至终浓度为0.016至1mg/ml，测定其最低抑菌浓度（MIC）。
结果
卵孢马拉色菌壳、竹叶状马拉色菌叶和油溶性马拉色菌提取物对两种菌株的MIC值相对较低（≤0.5mg/ml）。卵孢马拉色菌壳和油溶性马拉色菌提取物表现出特别高的活性，表明它们在脂溢性皮炎治疗中的潜在用途。这些提取物对其他常见的兼性致病酵母，如白色念珠菌和光滑念珠菌也表现出抑菌活性。
结论
卵孢马拉色菌壳和油溶性马拉色菌提取物有可能用作抗脂溢性和去屑洗发剂配方中的活性成分。它们有助于头皮脂溢性皮炎的反复治疗和定期预防。
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