Department of Cosmetic Applications and Management, Cardinal Tien Junior College of Healthcare and Management, New Taipei City, Taiwan.
Department of Dermatology, En Chu Kong Hospital, New Taipei City, Taiwan.
J Cosmet Dermatol. 2022 Aug;21(8):3423-3430. doi: 10.1111/jocd.14623. Epub 2021 Nov 18.
Scalp seborrheic dermatitis (SD) is a chronic inflammatory dermatosis associated with sebum imbalance and proliferation of Malassezia species. Various antifungal shampoos are commonly used for scalp SD.
Glycyrrhetinic acid is known to have antioxidative, anti-inflammatory, and anti-allergic effects. This study was designed to evaluate the effectiveness of a new-formula shampoo that contains glycyrrhetinic acid for the treatment of scalp SD.
PATIENTS/METHODS: Thirty-four patients were enrolled and treated with the 6% glycyrrhetinic acid complex shampoo. Efficacy was assessed clinically with Dermatology Life Quality Index (DLQI) and Adherent Scalp Flaking Score (ASFS) by the same dermatologist at baseline, week 2, and week 5. Among the 24 subjects with the most significant clinical improvement, four common microorganisms from scalp samples were analyzed by quantitative polymerase chain reaction (qPCR) at baseline, and week 5.
The DLQI and ASFS at week 2 and week 5 improved significantly relative to baseline. The bacteria profiles showed a significant increase of Cutibacterium acnes and a decrease of Staphylococcus epidermidis at week 5. The fungi profiles showed significant decreases of both Malassezia restricta and Malassezia globosa. The ratio of C. acne to S. epidermidis increased significantly from 0.93 at baseline to 1.55 at week 5. The ratio of M. restricta to M. globosa decreased from 5.02 at baseline to 1.00 at week 5.
The effectiveness of this new regimen was objectively demonstrated at the clinical and microbiological levels. This new formula may alleviate the bacterial and fungal dysbiosis in scalp SD.
头皮脂溢性皮炎（SD）是一种与皮脂失衡和马拉色菌属增殖有关的慢性炎症性皮肤病。各种抗真菌洗发水通常用于头皮 SD。
甘草酸具有抗氧化、抗炎和抗过敏作用。本研究旨在评估一种含有甘草酸的新型配方洗发水治疗头皮 SD 的疗效。
患者/方法：34 名患者接受了 6%甘草酸复合物洗发水的治疗。在基线、第 2 周和第 5 周，由同一位皮肤科医生使用皮肤病生活质量指数（DLQI）和附着头皮鳞屑评分（ASFS）进行临床评估。在 24 名临床改善最显著的受试者中，在基线和第 5 周时通过定量聚合酶链反应（qPCR）分析了来自头皮样本的四种常见微生物。
与基线相比，第 2 周和第 5 周的 DLQI 和 ASFS 显著改善。细菌谱显示，在第 5 周时，痤疮丙酸杆菌的数量显著增加，表皮葡萄球菌的数量减少。真菌谱显示，限制型马拉色菌和球形马拉色菌的数量均显著减少。从基线时的 0.93 到第 5 周时的 1.55，痤疮丙酸杆菌与表皮葡萄球菌的比值显著增加。从基线时的 5.02 到第 5 周时的 1.00，限制型马拉色菌与球形马拉色菌的比值显著降低。
该新方案在临床和微生物学水平上的有效性得到了客观证明。这种新配方可能缓解头皮 SD 中的细菌和真菌失调。
