Holdaway I M, Mountjoy K G
Aust N Z J Med. 1978 Dec;8(6):630-8. doi: 10.1111/j.1445-5994.1978.tb04853.x.
Receptors for progesterone were found in 27% of 98 human breast tumours, and for oestrogen in 57% of 191 tumours. With one exception, progesterone receptors were found only in tumours which also contained oestrogen receptors. Levels of oestrogen receptor in positive tumours rose significantly with patient age whereas progesterone receptors were unchanged. Progesterone receptor levels were lower in lymph node metastases than in primary tumours, and oestrogen receptor levels were lower in large tumours (greater than 5 cm diameter) compared to small lesions. Receptor levels were not significantly correlated with circulating concentrations of either oestrogen or prolactin. The implications of receptor measurements in assessing hormone responsiveness of breast tumours are discussed.
在98例人类乳腺肿瘤中，27%发现有孕激素受体；在191例肿瘤中，57%发现有雌激素受体。除1例例外，孕激素受体仅在也含有雌激素受体的肿瘤中发现。阳性肿瘤中雌激素受体水平随患者年龄显著升高，而孕激素受体水平则无变化。淋巴结转移灶中的孕激素受体水平低于原发肿瘤，大肿瘤（直径大于5厘米）中的雌激素受体水平低于小病灶。受体水平与雌激素或催乳素的循环浓度无显著相关性。本文讨论了受体测定在评估乳腺肿瘤激素反应性中的意义。
