Mitchell T J, Ketley J M, Burdon D W, Candy D C, Stephen J
J Med Microbiol. 1987 May;23(3):199-204. doi: 10.1099/00222615-23-3-199.
Clostridium difficile crude toxins and purified toxin A had similar effects on stripped rabbit ileal mucosa in Ussing chambers. Both toxin preparations caused secretion of sodium and chloride ions by increasing serosa to mucosa (s----m) fluxes. Transmural potential difference and resistance decreased after toxin treatment. Onset of changes in electrical measurements and ion fluxes coincided with onset of histological changes. The response to theophylline was greatly reduced in toxin-treated tissue compared with control tissue.
艰难梭菌粗毒素和纯化的毒素A对乌斯安室中剥离的兔回肠黏膜有相似的作用。两种毒素制剂均通过增加浆膜到黏膜（s----m）的通量导致钠离子和氯离子分泌。毒素处理后跨膜电位差和电阻降低。电测量和离子通量变化的开始与组织学变化的开始一致。与对照组织相比，毒素处理的组织对茶碱的反应大大降低。
