Ellis S R, Soltwisch J, Paine M R L, Dreisewerd K, Heeren R M A
M4I, The Maastricht Multimodal Molecular Imaging Institute, University of Maastricht, 6229 ER Maastricht, The Netherlands.
Chem Commun (Camb). 2017 Jun 29;53(53):7246-7249. doi: 10.1039/c7cc02325a.
Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.
将激光后电离与高分辨力基质辅助激光解吸电离傅里叶变换离子回旋共振质谱仪相结合，相对于传统基质辅助激光解吸电离，脂质基质辅助激光解吸电离质谱成像的灵敏度提高了约100倍，并扩大了化学覆盖范围。这可能成为生物医学研究的一项重大突破。
