激光后电离与高分辨轨道阱质谱仪相结合用于增强脂质的基质辅助激光解吸/电离质谱成像
Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids.
作者信息
Ellis S R, Soltwisch J, Paine M R L, Dreisewerd K, Heeren R M A
机构信息
M4I, The Maastricht Multimodal Molecular Imaging Institute, University of Maastricht, 6229 ER Maastricht, The Netherlands.
出版信息
Chem Commun (Camb). 2017 Jun 29;53(53):7246-7249. doi: 10.1039/c7cc02325a.
PMID:28573274
Abstract
Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.
摘要
将激光后电离与高分辨力基质辅助激光解吸电离傅里叶变换离子回旋共振质谱仪相结合，相对于传统基质辅助激光解吸电离，脂质基质辅助激光解吸电离质谱成像的灵敏度提高了约100倍，并扩大了化学覆盖范围。这可能成为生物医学研究的一项重大突破。
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