Shao Changdong, Lu Ailan, Wang Xiaoling, Zhou Bo, Guan Xiaohong, Zhang Yanghui
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P.R. China.
Org Biomol Chem. 2017 Jun 14;15(23):5033-5040. doi: 10.1039/c7ob01052d.
An efficient palladium-catalyzed hydroxycarbonylation reaction of arylhalides using oxalic acid as a CO source has been developed. The reaction features high safety, low catalyst loading, and a broad substrate scope, and provides a safe and tractable approach to access a variety of aromatic carboxylic acid compounds. Mechanistic studies revealed the decomposition pattern of oxalic acid.
已开发出一种高效的钯催化芳基卤化物的羟基羰基化反应，该反应使用草酸作为一氧化碳源。该反应具有高安全性、低催化剂用量和广泛的底物范围，并为获得各种芳香族羧酸化合物提供了一种安全且易于操作的方法。机理研究揭示了草酸的分解模式。
