Bayley A C, Downing R G, Cheingsong-Popov R, Tedder R S, Dalgleish A G, Weiss R A
Lancet. 1985 Feb 16;1(8425):359-61. doi: 10.1016/s0140-6736(85)91383-2.
Serum samples from African patients with Kaposi's sarcoma and acquired-immuno-deficiency-syndrome-related (AIDS-related) disorders and from normal subjects in Uganda and Zambia were tested for antibodies to the human T-lymphotropic retroviruses (HTLV) types I, II, and III. Nearly 90% of patients with AIDS-related disorders or with atypical, aggressive Kaposi's sarcoma were seropositive for HTLV-III in both countries, whereas only 17% of patients with classic endemic Kaposi's sarcoma were seropositive. Among the controls 20% were seropositive for HTLV-III in Uganda but only 2% in Zambia. None of the subjects tested had antibodies to HTLV-I or HTLV-II. These results are further evidence of the emergence of a clinically atypical form of Kaposi's sarcoma in Africans, which resembles that seen in American patients with AIDS, and which is associated with HTLV-III infection. The low frequency of antibodies to HTLV-III in the normal Zambian population together with the first appearance of HTLV-III-associated diseases during the past 2 years suggests that this virus is new to Zambia, although it may have been present in Uganda for longer.
对来自非洲患有卡波西肉瘤及与获得性免疫缺陷综合征相关（艾滋病相关）疾病的患者以及乌干达和赞比亚正常受试者的血清样本，检测了针对I型、II型和III型人类嗜T淋巴细胞逆转录病毒（HTLV）的抗体。在这两个国家，近90%患有艾滋病相关疾病或非典型侵袭性卡波西肉瘤的患者HTLV-III血清学呈阳性，而只有17%的经典地方性卡波西肉瘤患者血清学呈阳性。在对照组中，乌干达20%的人HTLV-III血清学呈阳性，而赞比亚只有2%。所有检测对象均未检测到针对HTLV-I或HTLV-II的抗体。这些结果进一步证明，非洲出现了一种临床非典型形式的卡波西肉瘤，它类似于美国艾滋病患者中所见的卡波西肉瘤，且与HTLV-III感染有关。赞比亚正常人群中HTLV-III抗体的低频率以及过去两年中首次出现HTLV-III相关疾病表明，这种病毒对赞比亚来说是新出现的，尽管它可能在乌干达已存在更长时间。
