Downing R G, Eglin R P, Bayley A C
Lancet. 1984 Mar 3;1(8375):478-80. doi: 10.1016/s0140-6736(84)92850-2.
16 Zambian patients with Kaposi's sarcoma (KS) were studied to determine whether they had evidence of lymphopenia with decreased T helper/T suppressor (Th/Ts) ratios or previous infection with opportunistic pathogens. Serological tests for viruses commonly associated with the acquired immunodeficiency syndrome (AIDS) were also carried out. 12 patients had a decreased Th/Ts and 2 of these were also lymphopenic. Serological evidence for infection with Toxoplasma and with Pneumocystis was present but this was not significantly more common in KS patients than in controls. All 16 patients had antibodies to cytomegalovirus (CMV), 15 had antibodies to Epstein-Barr virus and 13 to human T leukaemia virus (HTLV) infected cells. 5 patients had evidence of previous infection with hepatitis B virus. African patients with KS seem to have an immunological and virological profile similar to that seen in American patients with AIDS.
对16名赞比亚卡波西肉瘤（KS）患者进行了研究，以确定他们是否有淋巴细胞减少、T辅助/T抑制（Th/Ts）比值降低的证据，或既往是否感染过机会性病原体。还对通常与获得性免疫缺陷综合征（AIDS）相关的病毒进行了血清学检测。12名患者的Th/Ts比值降低，其中2名患者也有淋巴细胞减少。存在弓形虫和肺孢子虫感染的血清学证据，但这在KS患者中并不比对照组更常见。所有16名患者均有抗巨细胞病毒（CMV）抗体，15名有抗爱泼斯坦-巴尔病毒抗体，13名有抗人类T白血病病毒（HTLV）感染细胞的抗体。5名患者有既往感染乙型肝炎病毒的证据。非洲KS患者的免疫和病毒学特征似乎与美国艾滋病患者相似。
