Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2018 Apr;233(4):2928-2936. doi: 10.1002/jcp.26041. Epub 2017 Jun 30.
Colorectal cancer (CC) is often diagnosed at a late stage when tumor metastasis may have already occurred. Current treatments are often ineffective in metastatic disease, and consequently late diagnosis is often associated with poor outcomes in CC. Alternative strategies are therefore urgently required. An interaction between epithelial cancer cells and their tissue microenvironment is a contributor to metastasis, and therefore recent studies are beginning to focus on the properties of the tumor microenvironment and the mechanism by which the metastatic cells exploit the tumor microenvironment for survival, immune evasion, and growth. We have reviewed the development of the combined therapeutic approaches that have focused on targeting the microenvironment of CC.
结直肠癌（CC）通常在肿瘤转移可能已经发生的晚期阶段被诊断出来。目前的治疗方法在转移性疾病中往往无效，因此晚期诊断通常与 CC 的不良预后相关。因此，迫切需要替代策略。上皮癌细胞与其组织微环境之间的相互作用是转移的一个促成因素，因此最近的研究开始关注肿瘤微环境的特性以及转移细胞利用肿瘤微环境进行生存、免疫逃逸和生长的机制。我们回顾了集中针对 CC 微环境的联合治疗方法的发展。
