Deng Run-Zhi, Zheng Xin, Lu Zhong-Lei, Yuan Ming, Meng Qi-Chang, Wu Tao, Tian Yu
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China.
Department of Hepatobiliary Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
World J Gastrointest Oncol. 2024 Nov 15;16(11):4354-4368. doi: 10.4251/wjgo.v16.i11.4354.
The relevant mechanism of tumor-associated macrophages (TAMs) in the treatment of colorectal cancer patients with immune checkpoint inhibitors (ICIs) is discussed, and the application prospects of TAMs in reversing the treatment tolerance of ICIs are discussed to provide a reference for related studies. As a class of drugs widely used in clinical tumor immunotherapy, ICIs can act on regulatory molecules on cells that play an inhibitory role - immune checkpoints - and kill tumors in the form of an immune response by activating a variety of immune cells in the immune system. The sensitivity of patients with different types of colorectal cancer to ICI treatment varies greatly. The phenotype and function of TAMs in the colorectal cancer microenvironment are closely related to the efficacy of ICIs. ICIs can regulate the phenotypic function of TAMs, and TAMs can also affect the tolerance of colorectal cancer to ICI therapy. TAMs play an important role in ICI resistance, and making full use of this target as a therapeutic strategy is expected to improve the immunotherapy efficacy and prognosis of patients with colorectal cancer.
讨论了肿瘤相关巨噬细胞（TAMs）在免疫检查点抑制剂（ICIs）治疗结直肠癌患者中的相关机制，并探讨了TAMs在逆转ICIs治疗耐受性方面的应用前景，为相关研究提供参考。作为一类广泛应用于临床肿瘤免疫治疗的药物，ICIs可作用于起抑制作用的细胞上的调节分子——免疫检查点，并通过激活免疫系统中的多种免疫细胞以免疫反应的形式杀伤肿瘤。不同类型结直肠癌患者对ICI治疗的敏感性差异很大。结直肠癌微环境中TAMs的表型和功能与ICIs的疗效密切相关。ICIs可调节TAMs的表型功能，而TAMs也可影响结直肠癌对ICI治疗的耐受性。TAMs在ICI耐药中起重要作用，充分利用这一靶点作为治疗策略有望提高结直肠癌患者的免疫治疗疗效和预后。
