Gotelli C A, Astolfi E, Cox C, Cernichiari E, Clarkson T W
Science. 1985 Feb 8;227(4687):638-40. doi: 10.1126/science.2857500.
Phenylmercury absorbed through the skin from contaminated diapers affected urinary excretion in infants in Buenos Aires. The effects were reversible and quantitatively related to the concentration of urinary mercury. Excretion of gamma-glutamyl transpeptidase, an enzyme in the brush borders of renal tubular cells, increased in a dose-dependent manner when mercury excretion exceeded a "threshold" value. Urine volume also increased but at a higher threshold with respect to mercury. The results support the threshold concept of the systemic toxicity of metals. gamma-Glutamyl transpeptidase is a useful and sensitive marker for preclinical effects of toxic metals.
从受污染尿布经皮肤吸收的苯基汞影响了布宜诺斯艾利斯婴儿的尿排泄。这些影响是可逆的，并且在数量上与尿汞浓度相关。当汞排泄超过“阈值”时，肾小管细胞刷状缘中的一种酶——γ-谷氨酰转肽酶的排泄呈剂量依赖性增加。尿量也增加，但相对于汞而言阈值更高。这些结果支持了金属全身毒性的阈值概念。γ-谷氨酰转肽酶是有毒金属临床前效应的一种有用且敏感的标志物。
