Mohammed S, Chouhan Gurpreet, Anuforom Olachi, Cooke Megan, Walsh Anna, Morgan-Warren Peter, Jenkins Mike, de Cogan Felicity
Institute of Microbiology and Infection, University of Birmingham, UK.
School of Chemical Engineering, University of Birmingham, UK; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, UK.
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:203-209. doi: 10.1016/j.msec.2017.04.065. Epub 2017 Apr 12.
Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye drops on a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions.
微生物性角膜炎是一种严重的眼部疾病，也是全球范围内角膜瘢痕形成及相关失明的最常见原因之一。危险因素包括佩戴隐形眼镜、眼外伤、眼表疾病和免疫抑制。初始临床治疗要求至少48小时每小时或更频繁地局部应用广谱抗菌治疗，这可能需要住院，随后根据微生物学检查结果进行针对性治疗，并采取减轻炎症和促进愈合的策略。在这项研究中，我们报告了一种眼部伤口敷料，它可以包裹并持续释放不同的抗生素。使用这种敷料将使患者能够每4小时滴一次眼药水，从而提高治疗依从性并减少住院次数。
