Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Av Rogaciano Leite 900 apto 503, Torre Friburgo, Guararapes, Fortaleza, Ceará, Brazil.
Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
J Neurovirol. 2017 Aug;23(4):625-631. doi: 10.1007/s13365-017-0535-y. Epub 2017 Jun 2.
Chikungunya virus is an alphavirus transmitted by the mosquito Aedes, mainly Aedes aegypti and Aedes albopictus, that can cause acute illness, mostly self-limited, characterized by fever, maculopapular rash, and disabling polyarthritis/arthralgia, with an incubation period of 1 to 12 days. Chikungunya was largely regarded as a non-fatal and self-limited disease, but recently, serious cases have been reported including some with severe involvement of the nervous system, such as meningoencephalitis, myelitis, polyradiculitis, and polyradiculoneuropathy. In this report, we describe the clinical and laboratory findings of two patients with encephalitis associated with chikungunya in a northeastern city in Brazil, who exhibited a good outcome, with improvement after treatment with i.v. immunoglobulin (IVIg).
基孔肯雅热病毒是一种由蚊子传播的甲病毒，主要由埃及伊蚊和白纹伊蚊传播，可引起急性疾病，大多为自限性，以发热、斑丘疹和致残性多发性关节炎/关节痛为特征，潜伏期为 1 至 12 天。基孔肯雅热在很大程度上被认为是一种非致命且自限性的疾病，但最近有严重病例的报告，包括一些严重累及神经系统的病例，如脑膜炎、脊髓炎、多神经根炎和多神经根神经病。在本报告中，我们描述了巴西东北部一个城市的两例与基孔肯雅热相关的脑炎患者的临床和实验室发现，他们的预后良好，经静脉注射免疫球蛋白（IVIg）治疗后病情改善。
