Mehta K, Lopez-Berestein G, Moore W T, Davies P J
J Immunol. 1985 Apr;134(4):2053-6.
The culture of HPBM in serum-containing medium induced a large accumulation of the protein cross-linking enzyme, tissue TGase. Immune IFN enhanced the expression of tissue TGase in cultured monocytes. Enzyme-inducing activity, both in normal and IFN-treated cells, was completely blocked by depleting the serum of the lipid fraction. The readdition of retinol at a physiologic concentration (1 micron) to delipidized serum completely restored the enzyme-inducing activity in cultured monocytes. Thus, serum retinoids seem to play an important regulatory role in the expression of tissue TGase gene in differentiating human monocytes.
在含血清培养基中培养人早幼粒单核细胞（HPBM）可诱导蛋白交联酶——组织转谷氨酰胺酶大量积聚。免疫干扰素可增强培养单核细胞中组织转谷氨酰胺酶的表达。在正常细胞和经干扰素处理的细胞中，通过去除血清中的脂质部分，酶诱导活性完全被阻断。向脱脂血清中重新添加生理浓度（1微摩尔）的视黄醇可完全恢复培养单核细胞中的酶诱导活性。因此，血清类视黄醇似乎在分化的人单核细胞中组织转谷氨酰胺酶基因的表达中发挥重要的调节作用。
