Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland.
Office of the Director General, World Health Organization, Geneva, Switzerland.
Lancet. 2017 Nov 11;390(10108):2211-2214. doi: 10.1016/S0140-6736(17)31224-2. Epub 2017 May 31.
Diagnostics are crucial in mitigating the effect of disease outbreaks. Because diagnostic development and validation are time consuming, they should be carried out in anticipation of epidemics rather than in response to them. The diagnostic response to the 2014-15 Ebola epidemic, although ultimately effective, was slow and expensive. If a focused mechanism had existed with the technical and financial resources to drive its development ahead of the outbreak, point-of-care Ebola tests supporting a less costly and more mobile response could have been available early on in the diagnosis process. A new partnering model could drive rapid development of tests and surveillance strategies for novel pathogens that emerge in future outbreaks. We look at lessons learned from the Ebola outbreak and propose specific solutions to improve the speed of new assay development and ensure their effective deployment.
诊断对于减轻疾病爆发的影响至关重要。由于诊断的开发和验证需要耗费大量时间，因此应该在预期到流行病之前进行，而不是在应对它们时进行。2014-15 年埃博拉疫情的诊断反应虽然最终有效，但速度缓慢且代价高昂。如果存在一个具有技术和财务资源的重点机制，以在疫情爆发前推动其开发，那么在诊断过程的早期，就可以提供支持成本更低、更灵活的即时护理埃博拉检测。一种新的合作模式可以推动针对未来疫情中新出现的新型病原体的测试和监测策略的快速开发。我们从埃博拉疫情中吸取教训，并提出具体解决方案，以提高新检测方法的开发速度，并确保其有效部署。
