Wong T K, Everson R B, Hsu S T
Lancet. 1985 Mar 30;1(8431):721-4. doi: 10.1016/s0140-6736(85)91264-4.
Placental tissues were obtained from women in Taiwan who had ingested rice oil contaminated with aromatic polychlorinated hydrocarbons 3-4 years before conception. Known contaminants in the rice oil were polychlorinated biphenyls and their thermal degradation products, including polychlorinated dibenzofurans and polychlorinated quaterphenyls. Placental homogenates showed large increases in mono-oxygenase enzymes, including aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-de-ethylase, and diol, quinone, and phenolic metabolites of benzo(a)pyrene (analysed by high performance liquid chromatography). The findings suggest that exposure to these widespread, environmental pollutants may exert substantial and persistent metabolic effects.
胎盘组织取自台湾女性，这些女性在受孕前3至4年摄入了被芳香族多氯代烃污染的米糠油。米糠油中已知的污染物有多氯联苯及其热降解产物，包括多氯代二苯并呋喃和多氯代四联苯。胎盘匀浆显示单加氧酶大幅增加，包括芳烃羟化酶、7-乙氧基香豆素O-脱乙基酶，以及苯并(a)芘的二醇、醌和酚类代谢物（通过高效液相色谱法分析）。这些发现表明，接触这些广泛存在的环境污染物可能会产生重大且持久的代谢影响。
