[具体基因名称]和[具体基因名称]的上调与胃型腺癌的进展相关。
Up-Regulation of and Is Associated with The Progression of Gastric-Type Adenocarcinoma.
作者信息
Soleimani Farzad, Hajjari Mohammadreza, Mohammad Soltani Bahram, Behmanesh Mehrdad
机构信息
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
出版信息
Cell J. 2017 Spring;19(Suppl 1):66-71. doi: 10.22074/cellj.2017.4357. Epub 2017 May 17.
OBJECTIVE
Forkhead box (FOX) proteins are important regulators of the epithelial-to-mesenchymal transition (EMT), which is the main mechanism of cancer metastasis. Different studies have shown their potential involvement in progression of cancer in different tissues such as breast, ovary and colorectum. In this study, we aimed to analyze the expression of genes encoding two FOX proteins in gastric adenocarcinoma.
MATERIALS AND METHODS
In this experimental case-control study, the expression of and was examined in 31 gastric adenocarcinoma tumors and 31 normal adjacent gastric tissues by reverse transcription polymerase chain reaction (PCR).
RESULTS
The expression of both genes was significantly up-regulated in gastric adenocarcinoma tumors compared with the normal tissues (P<0.05). The differential expression of these two genes was also correlated with the grade of tumors (P<0.01).
CONCLUSION
We show that up-regulation of and are likely to be involved in the progression of gastric adenocarcinoma.
目的
叉头框（FOX）蛋白是上皮-间质转化（EMT）的重要调节因子，而EMT是癌症转移的主要机制。不同研究表明它们可能参与乳腺癌、卵巢癌和结直肠癌等不同组织的癌症进展。在本研究中，我们旨在分析胃腺癌中编码两种FOX蛋白的基因表达情况。
材料与方法
在本实验性病例对照研究中，通过逆转录聚合酶链反应（PCR）检测了31例胃腺癌肿瘤组织和31例正常胃旁组织中[具体基因名称缺失]和[具体基因名称缺失]的表达。
结果
与正常组织相比，胃腺癌肿瘤组织中这两个基因的表达均显著上调（P<0.05）。这两个基因的差异表达也与肿瘤分级相关（P<0.01）。
结论
我们表明[具体基因名称缺失]和[具体基因名称缺失]的上调可能参与胃腺癌的进展。
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