Couret Jennifer, Chang Theresa L
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.
Public Health Research Institute, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.
EC Microbiol. 2016;3(6):597-604. Epub 2016 Oct 18.
Reactive oxygen species (ROS) are a family of oxygen molecules with an unpaired electron and play an important role in homeostasis and pathogenesis. The reactive molecules modify lipids, proteins and nucleic acids, and modulate a wide range of cellular functions. The importance of ROS in infection has been established through clinical and in vitro studies. Here we review the role of oxidative stress in HIV pathogenesis, the impact of ROS on immune responses in HIV patients, and ROS-mediated regulation of HIV infection. Future studies on the interplay between ROS and HIV infection may offer a new strategy for prevention and treatment.
活性氧（ROS）是一类具有未配对电子的氧分子，在体内稳态和发病机制中发挥重要作用。这些活性分子会修饰脂质、蛋白质和核酸，并调节多种细胞功能。通过临床和体外研究，已经证实了ROS在感染中的重要性。在此，我们综述氧化应激在HIV发病机制中的作用、ROS对HIV患者免疫反应的影响以及ROS介导的HIV感染调控。未来关于ROS与HIV感染相互作用的研究可能会为预防和治疗提供新策略。
