Kayesh Mohammad Enamul Hoque, Kohara Michinori, Tsukiyama-Kohara Kyoko
Department of Microbiology and Public Health, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal, 8210, Bangladesh.
Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
Npj Viruses. 2025 Apr 12;3(1):27. doi: 10.1038/s44298-025-00110-3.
Viral infections can trigger increased reactive oxygen species (ROS) production and a reduced antioxidant response in the host, leading to redox stress, inflammation, apoptosis, and ultimately, cell and tissue damage, which contribute to disease development. A better understanding of how ROS contributes to viral pathogenesis is critical for the development of novel therapeutic interventions. In this review, we discuss the current knowledge on ROS production and its effects across various viral infections, including severe acute respiratory syndrome-coronavirus-2, influenza A virus, dengue virus, Zika virus, hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infections, to improve future therapeutic and preventive strategies for these infections.
病毒感染可引发宿主中活性氧（ROS）生成增加以及抗氧化反应减弱，导致氧化还原应激、炎症、细胞凋亡，并最终造成细胞和组织损伤，这些都促使疾病发展。更好地理解ROS如何促成病毒发病机制对于开发新型治疗干预措施至关重要。在本综述中，我们讨论了关于ROS生成及其在各种病毒感染中的作用的现有知识，包括严重急性呼吸综合征冠状病毒2、甲型流感病毒、登革热病毒、寨卡病毒、乙型肝炎病毒、丙型肝炎病毒和人类免疫缺陷病毒感染，以改进针对这些感染的未来治疗和预防策略。
