Dhital Subhash, Sherchand Jeevan Bahadur, Pokharel Bharat Mani, Parajuli Keshab, Mishra Shyam Kumar, Sharma Sangita, Kattel Hari Prasad, Khadka Sundar, Khatiwada Sulochana, Rijal Basista
National Public Health Laboratory, HIV Reference Unit, Kathmandu, Nepal.
Department of Microbiology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
BMC Res Notes. 2017 Jun 5;10(1):192. doi: 10.1186/s13104-017-2512-1.
Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigella spp. has challenged the situation. This study was conducted to determine the distribution of species and antibiotic susceptibility pattern of Shigella species isolated from stool specimen among children less than 5 years of age in Nepal.
Out of total 717 stool samples collected, 15 cases of Shigella spp. was isolated which includes 12 S. flexneri and 3 S. sonnei. Multidrug resistance was found among 13(86%) of the isolates. One of the isolates of S. flexneri was found to be ESBL-producer with MIC >256 mg/L for cefixime.
The high occurrence of multidrug resistance among Shigella spp. along with a case of ESBL-production for the first time in Nepal alarms the concerns about dissemination of the resistant isolates. So, systemic monitoring of the antimicrobial susceptibility pattern of Shigella spp. is becoming crucial to guide therapy.
志贺氏菌是资源匮乏国家细菌性肠胃炎的重要病因。志贺氏菌病的治疗大多需要使用抗生素。然而，志贺氏菌属中多重耐药性的增加以及超广谱β-内酰胺酶和环丙沙星耐药性的出现对这一情况构成了挑战。本研究旨在确定从尼泊尔5岁以下儿童粪便标本中分离出的志贺氏菌属的菌种分布及抗生素敏感性模式。
在总共收集的717份粪便样本中，分离出15例志贺氏菌属，其中包括12例福氏志贺氏菌和3例宋内志贺氏菌。13株（86%）分离株存在多重耐药性。发现一株福氏志贺氏菌分离株产ESBL，对头孢克肟的最低抑菌浓度>256mg/L。
志贺氏菌属中多重耐药性的高发生率以及尼泊尔首次出现产ESBL的病例，警示了对抗药菌株传播的担忧。因此，对志贺氏菌属的抗菌药物敏感性模式进行系统监测对于指导治疗变得至关重要。
