Kawada Akiyo, Kusano Motoyasu, Hosaka Hiroko, Kuribayashi Shiko, Shimoyama Yasuyuki, Kawamura Osamu, Akiyama Junichi, Yamada Masanobu, Akuzawa Masako
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showamachi, Maebashi-shi, Gunma 371-8511, Japan.
Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, 3-39-15 Showamachi, Maebashi-shi, Gunma 371-8511, Japan.
J Clin Biochem Nutr. 2017 May;60(3):211-215. doi: 10.3164/jcbn.16-53. Epub 2017 Apr 7.
We previously reported that cascade stomach was associated with reflux symptoms and esophagitis. Delayed gastric emptying has been believed to initiate transient lower esophageal sphincter relaxation (TLESR). We hypothesized that cascade stomach may be associated with frequent TLESR with delayed gastric emptying. Eleven subjects with cascade stomach and 11 subjects without cascade stomach were enrolled. Postprandial gastroesophageal manometry and gastric emptying using a continuous C breath system were measured simultaneously after a liquid test meal. TLESR events were counted in early period (0-60 min), late period (60-120 min), and total monitoring period. Three parameters of gastric emptying were calculated: the half emptying time, lag time, and gastric emptying coefficient. The median frequency of TLESR events in the cascade stomach and non-cascade stomach groups was 6.0 (median), 4.6 (interquartile range) vs 5.0, 3.0 in the early period, 5.0, 3.2 vs 3.0, 1.8 in the late period, and 10.0, 6.2 vs 8.0, 5.0 in the total monitoring period. TLESR events were significantly more frequent in the cascade stomach group during the late and total monitoring periods. In contrast, gastric emptying parameters showed no significant differences between the two groups. We concluded that TLESR events were significantly more frequent in persons with cascade stomach without delayed gastric emptying.
我们之前报道过，瀑布胃与反流症状及食管炎相关。胃排空延迟被认为会引发一过性下食管括约肌松弛（TLESR）。我们推测瀑布胃可能与胃排空延迟导致的频繁TLESR有关。招募了11名有瀑布胃的受试者和11名无瀑布胃的受试者。在液体试验餐后，同时使用连续C呼气系统测量餐后胃食管测压和胃排空情况。在早期（0 - 60分钟）、晚期（60 - 120分钟）和整个监测期统计TLESR事件。计算胃排空的三个参数：半排空时间、滞后时间和胃排空系数。瀑布胃组和非瀑布胃组TLESR事件的中位频率在早期分别为6.0（中位数）、4.6（四分位间距）对5.0、3.0，在晚期分别为5.0、3.2对3.0、1.8，在整个监测期分别为10.0、6.2对8.0、5.0。在晚期和整个监测期，瀑布胃组的TLESR事件明显更频繁。相比之下，两组的胃排空参数无显著差异。我们得出结论，在没有胃排空延迟的瀑布胃患者中，TLESR事件明显更频繁。
