提取物及其化合物对衰老大鼠脑抗氧化状态的调节作用。
Modulatory Effects of Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain.
作者信息
Sowbhagya Ramachandregowda, Anupama Siddhaghatta Kariyappa, Bhagyalakshmi Dundaiah, Anand Santosh, Ravikiran Tekupalli
机构信息
Department of Biotechnology, Jnana Bharathi Campus, Bangalore University, Bengaluru, Karnataka, India.
出版信息
J Pharm Bioallied Sci. 2017 Jan-Mar;9(1):8-15. doi: 10.4103/0975-7406.206219.
OBJECTIVE
The present study was aimed to investigate the neuroprotective effects of (Dh) aqueous root extract and its compounds against age-related oxidative stress (OS) in the discrete regions of the rat brain.
MATERIALS AND METHODS
Male Wistar albino rats of 4- and 22-month-old were divided into control and six supplemented groups. The supplemented groups were orally administered with ellagic acid (EA), 4-hydroxyisophthalic acid (4-HIA), and Dh extract for 30 days.
RESULTS
Age-related decrease in antioxidant enzyme activities was noticed. The hippocampus was found to be more vulnerable to OS as seen by the elevation in the OS markers. Supplementation of the Dh extract, EA, and 4-HIA was found to be effective in up-regulating the antioxidant status. However, the extent of up-regulation was more evident in Dh supplemented animals.
CONCLUSION
Our results suggest that Dh extract and its compounds exhibit neuroprotective effects against age-related OS and can be used as a dietary therapeutic intervention for the treatment of neurological disorders.
目的
本研究旨在探讨（Dh）根水提取物及其化合物对大鼠脑不同区域与年龄相关的氧化应激（OS）的神经保护作用。
材料与方法
将4月龄和22月龄的雄性Wistar白化大鼠分为对照组和六个补充组。补充组口服鞣花酸（EA）、4-羟基间苯二甲酸（4-HIA）和Dh提取物，持续30天。
结果
观察到与年龄相关的抗氧化酶活性下降。从OS标志物的升高可以看出，海马体对OS更敏感。发现补充Dh提取物、EA和4-HIA可有效上调抗氧化状态。然而，在补充Dh的动物中，上调程度更明显。
结论
我们的结果表明，Dh提取物及其化合物对与年龄相关的OS具有神经保护作用，可作为治疗神经疾病的饮食治疗干预措施。
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