Vela Driton, Leshoski Jovica, Gjorgievska Elizabeta S, Hadzi-Petrushev Nikola, Jakupaj Muharrem, Sopi Ramadan B, Mladenov Mitko
Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Institute of Biology, Faculty of Natural Sciences, Saints Cyril and Methodius University of Skopje, Skopje, Macedonia.
Oman Med J. 2017 May;32(3):195-200. doi: 10.5001/omj.2017.37.
Iron overload can cause or contribute to the pathogenesis of type 2 diabetes mellitus (T2DM), but how the major parameters of iron metabolism change in different settings of diabetes are still unclear. The aim of this study was to determine the relationship between iron, ferritin, and hepcidin levels in diabetic patients and the effect of insulin treatment.
The study included 80 subjects, 60 with T2DM and 20 without (control group). Serum hepcidin, insulin, ferritin, and iron levels were determined as well as other clinical parameters. The associations between these parameters were analyzed between both groups.
Hepcidin levels expressed as mean± standard deviation between groups showed no significant changes (14.4±6.7 ng/mL for the control group, and 18.4±7.9 ng/mL for patients with diabetes, 0.069). Parameters of iron metabolism showed modest correlation with the parameters of glucose metabolism. However, the correlation between ferritin and insulin in both groups was statistically significant ( 0.032; ρ = 0.480 vs. 0.011; ρ = 0.328).
Our study showed that hepcidin levels in patients with T2DM on insulin therapy do not change, which might be a result of treatment with insulin. In this context, insulin treatment can be used as a novel method for correction of hepcidin levels. By correcting hepcidin levels, we can prevent cellular iron overload and reduce the risk of diabetes.
铁过载可导致2型糖尿病（T2DM）发病或在其发病机制中起作用，但在不同糖尿病情况下铁代谢的主要参数如何变化仍不清楚。本研究旨在确定糖尿病患者铁、铁蛋白和铁调素水平之间的关系以及胰岛素治疗的效果。
该研究纳入80名受试者，其中60名T2DM患者和20名非糖尿病患者（对照组）。测定血清铁调素、胰岛素、铁蛋白和铁水平以及其他临床参数。分析两组之间这些参数的相关性。
两组间以均值±标准差表示的铁调素水平无显著变化（对照组为14.4±6.7 ng/mL，糖尿病患者为18.4±7.9 ng/mL，P = 0.069）。铁代谢参数与糖代谢参数呈适度相关。然而，两组中铁蛋白与胰岛素之间的相关性具有统计学意义（P = 0.032；ρ = 0.480 vs. P = 0.011；ρ = 0.328）。
我们的研究表明，接受胰岛素治疗的T2DM患者的铁调素水平未发生变化，这可能是胰岛素治疗的结果。在这种情况下，胰岛素治疗可作为纠正铁调素水平的一种新方法。通过纠正铁调素水平，我们可以预防细胞铁过载并降低糖尿病风险。
