Harmanci Duygu, Erkan Erdogan Pekcan, Kocak Ayse, Akdogan Gul Guner
Department of Molecular Medicine, Graduate School of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey.
Department of Medical Genetics, Medicum, University of Helsinki, 00014 Helsinki, Finland.
Biomed Rep. 2017 Jun;6(6):599-604. doi: 10.3892/br.2017.900. Epub 2017 May 3.
Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor-β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non-coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR-29 family is associated with fibrotic diseases. The aim of the present review is to provide an up-to-date summary of current knowledge on the latest developments associated with the miR-29 family and fibrotic skin diseases.
纤维化皮肤病的特征是胶原蛋白的积累。纤维化皮肤病的标志是成纤维细胞增殖和分化失衡、细胞外基质产生以及转化生长因子-β信号传导。许多研究探讨了微小RNA（miRNA或miR）参与某些纤维化疾病（包括皮肤、心脏、肺和肝脏疾病）发病机制的可能性。miRNA是一类小的非编码RNA，通过与靶信使RNA（mRNA）结合并阻断翻译或诱导靶mRNA降解来修饰基因表达。已经在生理和病理条件下研究了miRNA的生物学相关性，并且越来越多的证据表明miR-29家族与纤维化疾病有关。本综述的目的是提供有关miR-29家族与纤维化皮肤病相关最新进展的当前知识的最新总结。
