Poulet Blandine
Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Int J Exp Pathol. 2017 Jun;98(3):120-126. doi: 10.1111/iep.12230. Epub 2017 Jun 5.
Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the different stages of OA. This manuscript reviews the tissues and models that are being used to separate these stages of disease, in particular initiation and early and late progression. These models include human tissues with known initiating factors, the use of anatomical locations with defined relationships to the primary cartilage lesion area, timing of OA development in well-described animal models and the versatility of a non-invasive model of murine knee joint trauma.
骨关节炎（OA）是一种常见的慢性疾病，影响着越来越多的老年人群体。尽管其患病率很高，但目前尚无治疗方法。确定针对疾病发展特定致病阶段的新疗法依赖于有效区分骨关节炎的不同阶段。本文综述了用于区分疾病这些阶段的组织和模型，特别是起始阶段以及早期和晚期进展阶段。这些模型包括具有已知起始因素的人体组织、与原发性软骨损伤区域具有明确关系的解剖位置的使用、在详细描述的动物模型中骨关节炎发展的时间以及小鼠膝关节创伤非侵入性模型的多功能性。
