呼吁制定骨关节炎的标准化定义以及用于临床试验和临床应用的风险分层。
Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.
作者信息
Kraus V B, Blanco F J, Englund M, Karsdal M A, Lohmander L S
机构信息
Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Grupo de Proteomica, ProteoRed/ISCIII, Servicio de Reumatologia, Instituto de Investigación Biomedica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), As Xubias, 15006, A Coruña, Spain.
出版信息
Osteoarthritis Cartilage. 2015 Aug;23(8):1233-41. doi: 10.1016/j.joca.2015.03.036. Epub 2015 Apr 9.
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.
骨关节炎（OA）是一种异质性疾病。本综述的目标包括：（1）推动使用标准化的骨关节炎命名法，作为描述骨关节炎和定义骨关节炎表型的基础，简而言之，为这种异质性疾病提供统一的疾病概念；（2）推动建立类似于用于预测骨质疏松症骨折风险的FRAX™工具的OA发展风险（ROAD）和OA进展风险（ROAP）工具；（3）推动制定用于在影像学前期和/或分子阶段早期识别疾病的工具——可靠早期疾病识别（REDI）。围绕更敏感和特异的骨关节炎诊断标准达成共识，可能会促使针对这一迄今为止难以治疗的疾病实体开发疾病修饰疗法。我们完全认识到，随着我们不断前进，预计会制定出更完善的定义、术语和工具。
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