Muhammad Jibran Sualeh, Zaidi Syed Faisal, Saeed Sheikh Abdul, Ishaq Muhammad
Department of Biological and Biomedical Sciences, Faculty of Health Sciences, The Aga Khan University, Karachi, Pakistan & Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Sugitani 2630, Toyama, Japan.
Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Jeddah, Kingdom of Saudi Arabia.
J Pak Med Assoc. 2017 Jun;67(6):907-911.
Helicobacter pylori infection is considered the most commonly prevalent gastrointestinal pathogen where it manages to survive despite the hostile environment of human stomach, leading to various gastric diseases including gastric cancer. Due to the chronic inflammatory state induced by H. pylori and its interaction with host immune system have diverted researchers to investigate its correlation with systemic diseases outside of the gastrointestinal tract. This literature review was done to explore the association of H. pylori infection with haematological and cardiovascular diseases. We used medical subject heading (MeSH) terms "Helicobacter pylori" with "inflammation," "haematological diseases," "coronary heart diseases" or "vascular diseases" to search PubMed database. All relevant studies identified from 2005 to 2015 were included. As many of the studies are small-scale or showed weak association, further studies are needed to address the role of H. pylori in pathogenesis of haematological and cardiovascular diseases.
幽门螺杆菌感染被认为是最常见的胃肠道病原体，尽管人类胃部环境恶劣，它仍能存活，导致包括胃癌在内的各种胃部疾病。由于幽门螺杆菌诱导的慢性炎症状态及其与宿主免疫系统的相互作用，促使研究人员去探究它与胃肠道以外的全身性疾病之间的关联。进行这篇文献综述是为了探讨幽门螺杆菌感染与血液学和心血管疾病之间的关联。我们使用医学主题词（MeSH）“幽门螺杆菌”与“炎症”“血液学疾病”“冠心病”或“血管疾病”来检索PubMed数据库。纳入了所有在2005年至2015年期间鉴定出的相关研究。由于许多研究规模较小或显示出较弱的关联性，因此需要进一步的研究来阐明幽门螺杆菌在血液学和心血管疾病发病机制中的作用。
