1 Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University , Uppsala, Sweden .
2 Uppsala Clinical Research Center (UCR), Uppsala University , Uppsala, Sweden .
Metab Syndr Relat Disord. 2017 Sep;15(7):337-343. doi: 10.1089/met.2017.0006. Epub 2017 Jun 6.
Fat mass and fat distribution are major determinants of the metabolic syndrome (MetS), but the interplay between them has not been thoroughly investigated. In addition, fat mass and fat distribution are generally different in men than in women. We aimed to determine whether the interplay between fat mass and fat distribution regarding MetS and its components is sex-dependent using data from the large-scale population-based sample EpiHealth.
Occurrence of MetS and its components was determined together with fat mass by bioimpedance in 19,094 participants in the EpiHealth sample [mean age 61 years (SD 8.5), 56% females]. MetS was defined by the NCEP/ATPIII-criteria.
MetS prevalence was 23.0%. Fat mass (percent of body weight) was more strongly related to MetS (and the number of MetS components) in men than in women (P < 0.0001 for interaction term) and in those with a high compared with those with a low waist/hip ratio (WHR). This modulating effect of WHR on the fat mass versus MetS-relationship was more pronounced in women than in men (P < 0.0001 for interaction term). When analyzing the MetS components one by one, fat mass was more closely related to all the individual MetS criteria in men than in women, except for the glucose criteria.
Fat mass is more closely related to prevalent MetS in men than in women, but the modulating effect of an abdominal type of fat distribution on the fat mass versus MetS-relationship is stronger in women.
体脂肪量和脂肪分布是代谢综合征（MetS）的主要决定因素，但它们之间的相互作用尚未得到彻底研究。此外，男性和女性的体脂肪量和脂肪分布通常不同。我们旨在使用来自大规模基于人群的 EpiHealth 样本的数据，确定脂肪量和脂肪分布之间对 MetS 及其成分的相互作用是否存在性别依赖性。
在 EpiHealth 样本中的 19094 名参与者中，通过生物阻抗法确定 MetS 的发生及其组成部分（平均年龄 61 岁[标准差 8.5]，56%为女性）。MetS 通过 NCEP/ATPIII 标准定义。
MetS 的患病率为 23.0%。体脂肪量（体重的百分比）与 MetS（以及 MetS 成分的数量）的相关性在男性中强于女性（交互项 P < 0.0001），在腰围/臀围（WHR）较高的人群中强于较低的人群。WHR 对体脂肪量与 MetS 相关性的这种调节作用在女性中比男性中更为明显（交互项 P < 0.0001）。当逐一分析 MetS 成分时，除葡萄糖标准外，体脂肪量与男性中所有 MetS 单独标准的相关性均强于女性。
体脂肪量与男性中普遍存在的 MetS 更为密切相关，但腹部型脂肪分布对体脂肪量与 MetS 关系的调节作用在女性中更强。
